Abstract
This chapter will consider endogenous adenosine in the protection of the ischemic myocardium, the role of nucleoside transport inhibition in enhancing this protection, and the likely application of nucleoside transport inhibitors in clinical cardiovascular therapy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ely SW, Berne RM. Protective effects of adenosine in myocardial ischemia. Circulation 1992;85:93–904.
Van Belle H. Specific metabolically active antiischemic agents: adenosine and nuleoside transport inhibitors. Singh B, Dzau V, Vanhoutte P and Woosley R, editors. Cardiovascular Pharmacology and Therapeutics, Churchill Livingstone, NY, 1993;217–235.
Pepine CJ. New insights in measurement of myocardial ischemia. Am J Cardiol 1992;70:199–259.
Lawson CS, Downey JM. Preconditioning: state of the art myocardial protection. Cardiovasc. Res., 1993;27:542–550.
Forman MB, Velasco CE, Jackson EK. Adenosine attenuates reperfusion injury following regional myocardial ischemia. Cardiovasc Res 1993;127:9–17.
Gruber HE, Hoffer ME, McAllister DR, Laikind PK, Lane TA, Schmid-Schoenbein GW, Engler RL. Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury. Circulation 1989;10:1400–1411.
Van Belle H. Nucleoside transport inhibition: a therapeutic approach to cardioprotection via adenosine? Cardiovasc Res 1993;27:68–76.
Van Belle H, Janssen PAJ. Comparative pharmacology of nucleoside transport inhibitors. Nucleosides & Nucleotides 1991;10:975–982.
Sanz G, Pajaron A, AlegrÃa E, Coello I, Cardona M, et al. (GESIC). Prevention of early aortocornary bypass occlusion by low-dose aspirin and dipyridamole. Circulation 1990;82:765–773.
Cass CE, Gaudette LA, Paterson AP. Mediated transport of nucleosides in human erythrocytes: specific binding of the inhibitor nitrobenzylthioinosine to nucleoside transport sites in the erythrocyte membrane. Biochim Biophys Acta 1974;345:1–10.
Abd-Elfattah AS, Jessen ME, Hannan SA, Tuchy G, Wechsler AS. Is adenosine 5′-triphosphate derangement or free-radical-mediated injury the major cause of ventricular dysfunction during reperfusion? Circulation 1990;82(suppl. IV):341–350.
Abd-Elfattah AS, Ding M, Dyke CM, Wechsler AS. Protection of the stunned myocardium. Circulation 1993;88:336–343.
Van Belle H. The disappearance of adenosine in blood. Effect of lidoflazine and other drugs. Eur J Pharmacol 1970;11:241–248.
Van Belle H, Verheyen W, Ver Donck K, Janssen PAJ, Robertson JIS. Prevention of catecholamine-induced cardiac damage and death with a nucleoside transport inhibitor. J Cardiovasc Pharmacol 1992;20:173–178.
Dennis D, Martens J, Bellardinelli L. Frequency-dependent negative dromotropic effect of adenosine metabolism inhibitors in guinea pig heart. Drug Dev Res 1994;31:263 (Abstr).
Masuda M, Demeulemeester A, Chang-Chun C, Hendrikx M, Van Belle H, Flameng W. Cardioprotective effects of nucleoside transport inhibition in rabbit hearts. Ann Thorac Surg 1991;52:1300–1305.
Van Belle H, Goossens F, Wynants J. Biochemical and functional effects of nucleoside transport inhibition in the isolated cat heart. J Mol Cell Cardiol 1989;21:797–805.
Masuda M, Chang-Chun C, Möllhoff T, Van Belle H, Flameng W. Effects of nucleoside transport inhibition on long-term ex vivo preservation of canine hearts. J Thorac Cardiovasc Surg 1992;104,1610–1617.
Flameng W, Sukehiro S, Möllhoff T, Van Belle H, Janssen PAJ. A new concept of long-term donor heart preservation: nucleoside transport inhibition. J Heart and Lung Transplant 1992;10:990–998.
Vandeplassche G, Hermans C, D’Aubioul J, Van Belle H. Effect of nucleoside transport inhibition on the contractile function of stunned myocardium. Circulation 1991;84(Suppl II):A2607.
Itoya M, Miura T, Urabe K, Ishimoto R, Iimura O. Nucleoside transport inhibitors enhanced the infarct size-limiting effect of preconditioning. Circulation 1992;86(Suppl. I):I–25.
Wainwright CL, Parratt JR, Van Belle H. The antiarrhythmic effects of the nucleoside transport inhibitor, R 75231, in anaesthetised pigs. Br J Pharmacol 1993;109:592–599.
Kirkebøen K, Illebekk A, Tønessen T, Leistad E, Naes PA, Christensen G, Aksness G. Cardiac contractile function following repetitive brief ischemia: effects of nucleoside transport inhibition. Am J Physiol 1994;267;H57–H65.
De Haan HH, De Haan J, Van Reempts JLH, Van Belle H, Hasaart THM. The effect of adenosine transport inhibition on cardiovascular function and survival after severe asphyxia in fetal lambs. Pediatr Res 1993;33:185–189.
Antiplatelet Trialists’ Collaboration. Collaborative overview of randomized trials of antiplatelet therapy — I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Br Med J 1994;308:81–106.
Shepard LY. The competitive market for antiplatelets and thrombolytics: can a new entrant succeed? TIBTECH 1991;80–85.
Hernandez R, Alemany M, Bozzo J, Buchanan MR, Ordinas A, Bastida E. Platelet adhesivity to subendothelium is influenced by polymorphonuclear leukocytes: studies with aspirin and salicylate. Haemostasis 1993;23:1–7.
Cronstein BN. Adenosine, an endogenous anti-inflammatory agent. J Appl Physiol 1994;76:5–13.
Nolte D, Lehr HA, Messmer K. Adenosine inhibits postishemic leukocyte-endothelium interaction in postcapillary venules of the hamster. Am J Physiol 1991;261:H651–H655.
de la Harpe J, Nathan CF. Adenosine regulates the respiratory burst of cytokine-triggered human neutrophils adherent to biologic surfaces. J Immunol 1989;143:596–602.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Kluwer Academic Publishers
About this chapter
Cite this chapter
Van Belle, H. (1996). Myocardial Protection Using Nucleoside Transport Inhibitors. In: Abd-Elfattah, AS.A., Wechsler, A.S. (eds) Purines and Myocardial Protection. Developments in Cardiovascular Medicine, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0455-5_11
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0455-5_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-8056-6
Online ISBN: 978-1-4613-0455-5
eBook Packages: Springer Book Archive