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Potassium Channel Activation and Arrhythmogenicity

  • Chapter
Myocardial Protection and the KATP Channel

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 179))

  • 31 Accesses

Abstract

It may be expected that potassium channel openers (KCOs), in particular openers of the ATP sensitive K+ channel, will become increasingly available for the treatment of angina pectoris and hypertension. It is therefore important to define possible proarrhythmic effects of KCOs especially in the setting of acute ischemia. As will be shown there are surprisingly few experimental data allowing a firm conclusion be made regarding this important issue. A discussion about pro- and anti-arrhythmic effects of KCOs is confounded by a number of factors, of which the most important are: dosage, species differences, experimental models (notably in vivo experiments versus experiments on isolated preparations or myocytes), heart rate, and in the setting of ischaemia the time after coronary artery occlusion. We will firstly discuss the effects of KCOs on normoxic cardiac tissue before focusing on ischaemia-induced arrhythmias.

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Author information

Authors and Affiliations

  1. Department of Experimental & Clinical Cardiology, M-0-52, Academic Medical Center, University of Amsterdam, P.O.Box 22700, 1100 De, Amsterdam, The Netherlands

    Michiel J. Janse & Arthur A. M. Wilde

Authors
  1. Michiel J. Janse
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  2. Arthur A. M. Wilde
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Editors and Affiliations

  1. University College London Medical School & Hospitals, London, UK

    Derek M. Yellon Ph.D., DSc. MRCP(Hon), FESC, FACC (Professor of Cellular Cardiology, Head of the Division of Cardiology & Director of the Hatter Institute) (Professor of Cellular Cardiology, Head of the Division of Cardiology & Director of the Hatter Institute)

  2. Department of Pharmacology & Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, 53226, USA

    Garrett J. Gross B.S., M.S., Ph.D. (Professor of Pharmacology & Toxicology) (Professor of Pharmacology & Toxicology)

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© 1995 Kluwer Academic Publishers

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Janse, M.J., Wilde, A.A.M. (1995). Potassium Channel Activation and Arrhythmogenicity. In: Yellon, D.M., Gross, G.J. (eds) Myocardial Protection and the KATP Channel. Developments in Cardiovascular Medicine, vol 179. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0453-1_5

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  • DOI: https://doi.org/10.1007/978-1-4613-0453-1_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8055-9

  • Online ISBN: 978-1-4613-0453-1

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