Fimbriae—Mediated Adherence Induces Cosal Inflammation and Bacterial Clearance
Escherichia colistrains express a variety of fimbrial and non-fimbrial adherence factors which bind via lectin-receptor interactions to host cell glycoconjugate receptors. The attached state provides several advantages; it allows bacteria to resist elimination by the flow of secretions, it enhances their ability to trap nutrients, to multiply and to colonize the mucosa. Attachment may indeed be the endpoint for microbes that form part of the indigenous flora at different mucosal sites. For the pathogens however, adherence is only the first step in a complex series of events that lead to disease. The pathogens may activate the mucosal cells to which they bind, may invade into and through those cells, and may disrupt the integrity of the mucosal cell layer to reach underlying tissue compartments. Common to these events is the induction of an inflammatory response in the mucosa.
KeywordsA498 Cell Cytokine Response Acute Pyelonephritis Acute Cystitis Bacterial Persistence
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- Anderson, P., Engberg, I., Lidin-Janson, G., Lincoln, K., Hull, R.,Hull, S. and Svanborg-Edén, C. (1991) Infect. Immun. 59, 2915–2921Google Scholar
- Giampapa C, Abraham S, Chiang T, and Beachey E. (1988) J Biol. Chem. 263, 5362–5367Google Scholar
- Hedlund, M, Svensson, M., Nilsson, Å., Duan, R-D, and Svanborg, C. (1996) J. Exp. Med183:in pressGoogle Scholar
- Johnson, J. (1991) Clin. Microbial. Rev. 4, 80–128Google Scholar
- Klemm, P., and Krogfelt, K. (1994) in Fimbriae; Adhesion, Genetics, Biogenesis, and Vaccinesed. Klemm, P. (CRC Press, Boca Raton), pp. 9–26Google Scholar
- Linder, H., Engberg, I., Mattsby-Baltzer, I., Jann, K., and Svanborg-Edén, C. (1988) Infect. Immun56:1039- 1313Google Scholar
- Linder, H., Engberg, I., Hoschüttzky, H., Mattsby-Baltzer, I., and Svanborg, C. (1991) infect. Immun. 59:4357–4362Google Scholar
- Sharon, N., and Ofek, I. (1986) In Microbial lectins and agglutinins: properties and biological activity, ed. Mirelman, D. (Wiley and sons. New York), pp. 55–82Google Scholar
- Sokurenko, E., Courtney, H., Maslow, J., Siitonen, A., and Hasty, D. (1995) J. Bacteriol(In press).Google Scholar
- Svanborg, C., Ørskov, F., and Ørskov, I. (1994) in Fimbriae; Adhesion, Genetics, Biogenesis, and Vaccinesed. Klemm, P. (CRC Press, Boca Raton), pp. 239–254Google Scholar