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Fimbriae—Mediated Adherence Induces Cosal Inflammation and Bacterial Clearance

Consequences for Anti-Adhesion Theraphy
  • Hugh Connell
  • William Agace
  • Maria Hedlund
  • Per Klemm
  • Mark Shembri
  • Catharina Svanborg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 408)

Abstract

Escherichia colistrains express a variety of fimbrial and non-fimbrial adherence factors which bind via lectin-receptor interactions to host cell glycoconjugate receptors. The attached state provides several advantages; it allows bacteria to resist elimination by the flow of secretions, it enhances their ability to trap nutrients, to multiply and to colonize the mucosa. Attachment may indeed be the endpoint for microbes that form part of the indigenous flora at different mucosal sites. For the pathogens however, adherence is only the first step in a complex series of events that lead to disease. The pathogens may activate the mucosal cells to which they bind, may invade into and through those cells, and may disrupt the integrity of the mucosal cell layer to reach underlying tissue compartments. Common to these events is the induction of an inflammatory response in the mucosa.

Keywords

A498 Cell Cytokine Response Acute Pyelonephritis Acute Cystitis Bacterial Persistence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Hugh Connell
    • 1
  • William Agace
    • 1
  • Maria Hedlund
    • 1
  • Per Klemm
    • 2
  • Mark Shembri
    • 2
  • Catharina Svanborg
    • 1
  1. 1.Department of Medical Microbiology, Section of Clinical ImmunologyLund UniversityLundSweden
  2. 2.Department of MicrobiologyThe Technical University of DenmarkLyngbyDenmark

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