Adhesion and Invasion of Escherichia Coli
Escherichia coli are well known as part of the intestinal flora of healthy individuals. However, there are several groups of E. coli strains which are important pathogens. These E. coli strains cause intestinal diseases as enteritis, diarrhea, or dysentery. Furthermore, certain E. coli strains are responsible for extraintestinal diseases like urinary tract infections (UTI), sepsis, or meningitis. E. coli are among the most frequent causes for intestinal diseases and urinary tract infections. In order to prevent infection by these microorganisms, it is necessary to understand on a molecular level the pathophysiology of diseases caused by E. coli. It seems reasonable to try to block already the very first steps of infection in order to prevent developement of disease. These very first steps are adhesion and/or invasion to/into host cells. This article will focus on S-fimbriae of UTI and meningitis causing E. coli (MENEC) as an example of an adhesin as a virulence factor as well as on the ability of MENEC and enterohemorrhagic E. coli (EHEC) to invade nonprofessional phagocytes.
KeywordsBrain Microvascular Endothelial Cell Invasion System Fimbrial Subunit Efficient Invasion Extraintestinal Disease
Unable to display preview. Download preview PDF.
- 1.Ritter, A., Blum, G., Emödy, L., Kerenyi, M., Böck, A., Neuhierl, B., Rabsch, W., Scheutz, F., and Hacker, J. 1995. tRNA genes and pathogenicity islands: influence on virulence and metabolic properties of uropathogenic Escherichia coli. Mol. Microbiol. 17:109–121.Google Scholar
- 2.Hacker, J., Schmidt, G., Hughes, C., Knapp, S., Marget, M., and Goebel., W. 1985. Cloning and characterization of genes involved in production of mannose-resistant, neuraminidase-suseptible (X) fimbriae from a uropathogenic 06:K15:H31 Escherichia coli strain. Infect. Immun. 47:434–440.PubMedGoogle Scholar
- 5.Schmoll, T., Hoschützky, H., Morschhäuser, J., Lottspeich, F., Jann, K., and Hacker, J. 1989. Analysis of genes coding for the sialic acid-binding adhesin and two other minor fimbrial subunits of the S fimbrial adhesin determinant of Escherichia coli. Mol. Microbiol. 3:1735–1744.PubMedCrossRefGoogle Scholar
- 7.Morschhäuser, J., Vetter, V., Korhonen, T., Uhlin, B.E., and Hacker, J. 1993. Regulation and binding properties of S fimbriae cloned from E. coli strains causing urinary tract infection and meningitis. Zbl. Bakt. 278:165–176.Google Scholar
- 14.Straube, E., Schmidt, G., Marre, R., and Hacker, J. 1993. Adhesion and internalization of E. coli strains expressing various pathogenic determinants. Zbl. Bakt. 278:218–228.Google Scholar
- 15.Meier, C., Oelschlaeger, T.A., Merkert, H., Korhonen, T.K., and Hacker, J. 1996. Ability of the new born meningitis isolate Escherichia coli IHE 3034 (018:K1:H7) to invade epithelial and endothelial cells. Infect. Immun., in press.Google Scholar