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Adhesion and Invasion of Escherichia Coli

Studies on Function and Regulation
  • T. A. Oelschlaeger
  • J. Morschhäuser
  • C. Meier
  • C. Schipper
  • J. Hacker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 408)

Abstract

Escherichia coli are well known as part of the intestinal flora of healthy individuals. However, there are several groups of E. coli strains which are important pathogens. These E. coli strains cause intestinal diseases as enteritis, diarrhea, or dysentery. Furthermore, certain E. coli strains are responsible for extraintestinal diseases like urinary tract infections (UTI), sepsis, or meningitis. E. coli are among the most frequent causes for intestinal diseases and urinary tract infections. In order to prevent infection by these microorganisms, it is necessary to understand on a molecular level the pathophysiology of diseases caused by E. coli. It seems reasonable to try to block already the very first steps of infection in order to prevent developement of disease. These very first steps are adhesion and/or invasion to/into host cells. This article will focus on S-fimbriae of UTI and meningitis causing E. coli (MENEC) as an example of an adhesin as a virulence factor as well as on the ability of MENEC and enterohemorrhagic E. coli (EHEC) to invade nonprofessional phagocytes.

Keywords

Brain Microvascular Endothelial Cell Invasion System Fimbrial Subunit Efficient Invasion Extraintestinal Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • T. A. Oelschlaeger
    • 1
  • J. Morschhäuser
    • 1
  • C. Meier
    • 1
  • C. Schipper
    • 1
  • J. Hacker
    • 1
  1. 1.Institut für Molekulare InfektionsbiologieUniversität WürzburgWürzburgGermany

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