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Microbial Coaggregation in the Oral Cavity

  • Ervin I. Weiss
  • Blanka Shenitzki
  • Roni Leibusor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 408)

Abstract

Gingivitis and periodontitis are the most common human diseases with bacterial etiology. Almost all adults worldwide experience gingivitis and some degree of periodontitis. Gingivitis can persist for prolonged periods without significant progression or can serve as a precursor to periodontitis in susceptible individuals. Periodontitis lesions are virtually irreversible and exhibit destruction of the connective tissue attachment, apical migration of the junctional epithelium and resorption of the adjacent alveolar bone. Clinically, it results in deep periodontal pockets, exposure of the root cementum to the oral environment, and eventual loss of dentition. The natural occurrence of initiation and subsequent progression of periodontal disease has been followed in a homogeneous population in Sri Lanka over a 20 year period (Loe, 1986). This study has shown that in the complete absence of oral hygiene and oral health care, all participants exhibited visible plaque, gingivitis and supra- and subgingival calculus in all teeth. But despite the remarkable homogeneity of the group, the severity of the disease among individuals varied greatly. On the basis of the rate of periodontal attachment loss, this population could be divided into three groups: (i) those who showed rapidly progressing periodontitis (approximately 8%), (ii) those who showed moderately progressing periodontitis (80%), and (iii) a small but significant group who exhibited no progression of the disease beyond chronic gingivitis. It is the observation of this last group which challenges the understanding of the mechanism(s) of how and what turns on the progression of the periodontal lesion, and how it is turned off. This is still unresolved.

Keywords

Oral Hygiene Dental Plaque Oral Bacterium Cranberry Juice Bacterial Etiology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. Adriaene PA, De Boever A, Loesche WJ. Bacterial invasion in root cementum and radicular dentin of periodontally diseased teeth in humans. A reservoir of periodontopathic bacteria. J Periodontol 1988;59:222–230.Google Scholar
  2. Alaluusua S, Asikainen S, Lai C-H. Intrafamilial transmission of Actino-bacillus actinomycetemcomitans. J Periodontol 1991;62:207–210.PubMedGoogle Scholar
  3. Bauman A. Reaggregation of dental plaque. DMD Thesis, Tel Aviv University, Tel Aviv, Israel 1991.Google Scholar
  4. Cassels FJ, London J. Isolation of a coaggregation-inhibiting cell wall poly-saccharide from Streptococcus sanguis Hl. J Bacteriol 1989;171:4019–4025.PubMedGoogle Scholar
  5. Cassels FJ, Fales HM, London J, Carlson RW, van Haibeek H. Structure of a streptococcal adhesin carbohydrate receptor. J Biol Chem 1990;265:14127–14135.PubMedGoogle Scholar
  6. Cisar JOS, Kolenbrander PE, Mclntire FC. The specificity of coaggregation reactions between human oral streptococci and strains of Actinomyces viscosus or Actinomyces naeslundii. Infect Immun 1979;24:742–752.PubMedGoogle Scholar
  7. Gibbons RJ, Nygaard M. Interbacterial aggregation of plaque bacteria. Arch Oral Biol 1970;15:1397–1400.PubMedCrossRefGoogle Scholar
  8. Gibbons RJ, Hay DI, Schlesinger DH. Delineation of a segment of adsorbed salivary proline-rich proteins which promotes adhesion of Streptococcus gordonii to apatitic surfaces. Infect Immun 1991;59:2948- 2954.PubMedGoogle Scholar
  9. Haffajjee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. In: Socransky SS, Haffajjee AD (eds.), Microbiology and immunology of periodontal diseases. Periodontol 2000 1994;5:78–111.Google Scholar
  10. Kagermeier A, London J. Identification and preliminary characterization of a lectin like protein from Capnocytophaga gingivalis (emended). Infect Immun 1986;51:490–494.PubMedGoogle Scholar
  11. Kaufman J, DiRienzo JM. Evidence for the existence of two classes of corncob (coaggregation) recetor in Fusobacterium nucleatum. Oral Microbiol Immunol 1988;3:145–152.PubMedCrossRefGoogle Scholar
  12. Kinder SA, Holt SC. Localization of the Fusobacterium nucleatum. T18 adhesin activity mediating coaggregation with Porphyromonas gingivalis T22. J Bacteriol 1993;175:840–850.PubMedGoogle Scholar
  13. Kolenbrander PE, Andersen RN. Cell to cell interactions of Capnocytophaga and Bacteroides species with other oral bacteria and their potential role in development of plaque. J Periodontal Res 1984; 19:564–569.PubMedCrossRefGoogle Scholar
  14. Kolenbrander PE, Andersen RN. Inhibition of coaggregation between Fuso-bacterium nucleatum and Porphyromonas (Bacteroides) gingivalis by lactose and related sugars. Infect Immun 1989;57:3204–3209.PubMedGoogle Scholar
  15. Kolenbrander PE, London J. Adhere today, here tomorrow: Oral bacterial adherence. J Bacteriol 1993;175:3247–3252.PubMedGoogle Scholar
  16. Kolenbrander PE, Andersen RN, Moore LVH. Coaggregation of Fuso-bacterium nucleatum, Selenomonas flueggei, Selenomonas infelix, Selenomonas noxia, and Selenomonas sputigena with strains from 11 genera of oral bacteria. Infect Immun 1989;57:3194–3204.PubMedGoogle Scholar
  17. Kolenbrander PE, Ganeshkumar N, Carrels FJ, Hughes CV. Coaggregation: Specific adherence among human and plaque bacteria. FASEB J 1993;7: 406–413.PubMedGoogle Scholar
  18. Loe H. Progression of natural untreated periodontal disease in man. In: Lhener T, Gimasoni G (eds.), The Borderland Between Caries and Periodontal Disease III. Editions Medicine et Hygiene, Geneva, 1986:11–29.Google Scholar
  19. Mclntire FC, Vatter AE, Baros J, Arnold J. Mechanism of coaggregation between Actinomyces viscosus T14V and Streptococcus sanguis 34. Infect Immun 1978;21:978–988.Google Scholar
  20. Moore WEC, Moore LVH. In: Socransky SS, Haffajjee AD (eds.) Micro-biology and immunology of periodontal diseases. Periodontol 2000 1994;5: 78–111.Google Scholar
  21. Nyvad B, Kilian M. Comparison of the initial streptococcal microflora on dental enamel in caries-active and in caries-inactive individuals. Caries Res 1990;24:267–272.PubMedCrossRefGoogle Scholar
  22. Rosenberg M, Judes H, Weiss E. Cell surface hydrophobicity of dental plaque microorganisms in situ. Infect Immun 1983;42:831–834.PubMedGoogle Scholar
  23. Takemoto T, Ozaki M, Shirakawa M, Hino T, Okamoto H. Purification of arginine-sensitive hemagglutinin from Fusobacterium nucleatum and its role in coaggregation. J Periodontal Res 1993;28:21–26.PubMedCrossRefGoogle Scholar
  24. van Houte J. Bacterial speificity in the etiology of dental caries. Int Dent J 1980;30:305–326.PubMedGoogle Scholar
  25. van Steenbergen TJJM, Petit MDA, Scholte LHM, van der Velden UU, de Graaff. Transmission of Porphyromonas gingivalis between spouses. J Clin Periodontol 1993;20: 340–345.PubMedCrossRefGoogle Scholar
  26. van Winkellhoff AJ, van der Velden U, Clement M, de Graaff J. Intraoral distribution of black-pigmented Bacteroides species in periodontitis patients. Oral Microbiol Immunol 1988;3:83–85.CrossRefGoogle Scholar
  27. Weiss EI, Eli I, Shenitzki B, Smorodinsky N. Identification of the rhamnose-sensitive adhesin of Capnocytophaga ochracea ATCC 33596. Arch Oral Biol 1990;35 (Suppl): 127S-130S.PubMedCrossRefGoogle Scholar
  28. Weiss EI, London J, Kolenbrander PE, Andersen RN, Fischler C, Siraganian R. Characterization of monoclonal antibodies to fimbria-associated adhesins of Bacteroides loeschei PK 1295. Infect Immun 1988;56:219–224.PubMedGoogle Scholar
  29. Weiss EI, Kolenbrander PE, London J, Hand AR, Andersen RN. Fimbriae-associated proteins of Bacteroides loeschei PK1295 mediate intergeneric coaggregations. J Bacteriol 1987a;169:4215–4222.PubMedGoogle Scholar
  30. Weiss EI, London J, Kolenbrander PE, Kagermeier AS, Andersen RN. Characterization of lectin like surface components on Capnocytophaga ochracea ATCC 33596 that mediate coaggregation with gram-positive oral bacteria. Infect Immun 1987b;55:1198–1202.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Ervin I. Weiss
    • 1
  • Blanka Shenitzki
    • 1
  • Roni Leibusor
    • 1
  1. 1.The Maurice and Gabriela Goldschleger School of Dental MedicineTel Aviv UniversityTel AvivIsrael

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