Trichomonas vaginalis Adhesin Proteins Display Molecular Mimicry to Metabolic Enzymes
Trichomonas vaginalis is a flagellated protozoan responsible for trichomonosis, one of the most prevalent sexually transmitted diseases. Women are mainly affected and have a broad range of symptomatology; minor irritation to severe inflammation of the vaginal epithelium, accompanied with discharge, itching and abdominal pain have been reported (Krieger et al., 1990). Because of these varied symptoms and the lack of a good clinical test, diagnosis is less than adequate with approximately 50% of women misdiagnosed.
KeywordsMalic Enzyme AP65 Gene Host Cell Surface Vaginal Epithelial Cell TRICHOMONAS VAGINALIS
Unable to display preview. Download preview PDF.
- Alderete, J.F., and Garza, G.E., 1987, Trichomonas vaginalis attachment to host cell surfaces and role of cytoadherence in cytotoxicity, Acta Universitatis Carolinae - Biologica. 10:373–380.Google Scholar
- Bramley, M., 1976, Study of female babies of women entering confinement with vaginal trichomoiasis, Brit. J. Vener. Dis. 52:58–62.Google Scholar
- Cohen, M.S., Britigan, B.E., French, M., and Bean, K., 1987, Preliminary observations on lactoferrin secretion in human vaginal mucus: variation during menstrual cycle, evidence of hormonal regulation and implications for infection with Neisseria gonorrhoeae, Am. J. Obstet. Gynecol 157:1122–1125.PubMedGoogle Scholar
- Holz, G.G., Lindmark, D.G., Beach, D.J., Neale, K.A., Singh, B.N., 1987, Lipids and lipid metabolism of trichomonads, symposium on trichomonads and trichomoniasis, Acta Unversitatis Carolinae-Bi-ologica, Praque, Czechoslovakia.Google Scholar
- Hsu, R.Y., Glynias, M.J., Satterlee, J., Feeney, R., Clarke, A.R., Emery, D.C., Roe, B.A., Wilson, R.K., Goodridge, A.G., and Holbrooks, J.J., 1992, Duck liver malic enzyme expression in Escherichia coli and characterization of the wild-type enzyme and site-directed mutants, Biochem. J. 284:869–876.PubMedGoogle Scholar
- Laga, M.A., Manoka, A., Kivuvu, M., Malele, B., Tuliza, M., Nzila, N., Goeman, J., Behets, F., Batter, V., Alary, M., Heyward, W.L., Ryder, R.W., Piot, P., 1993, Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study, AIDS. 7:95–102.PubMedCrossRefGoogle Scholar
- Lindmark, D.G., 1983, Failure of trichomonads to convert or retroconvert long chain fatty acids or cholesterol, J. Protozool. 30:5A.Google Scholar
- Lou, G.X., and Nishimura, J.S., 1991, Site-directed mutagenesis of Escherichia coli succinyl- CoA synthetase, J. Biol. Chem. 266:20781–20785.Google Scholar
- Minkoff, H., Grunebaum, A.N., Schwarz, R.H., Feldman, J., Cummings, M., Crobleholme, W., Clark, L., Pringle, G., and McCormack, W.M., 1984, Risk Factors for prematurity and premature rupture of membranes: a prospective study of the vaginal flora in pregnancy, Am. J. Obstet. Gynecol. 150:965 –972.PubMedGoogle Scholar
- O’Brien, J.L., Lauriano, C.M., and Alderete, J.F., 1996, Molecular characterization of a third AP65 adhesin gene of Trichomonas vaginalis, Microbial Pathogen. In press.Google Scholar