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Trichomonas vaginalis Adhesin Proteins Display Molecular Mimicry to Metabolic Enzymes

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Toward Anti-Adhesion Therapy for Microbial Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 408))

Abstract

Trichomonas vaginalis is a flagellated protozoan responsible for trichomonosis, one of the most prevalent sexually transmitted diseases. Women are mainly affected and have a broad range of symptomatology; minor irritation to severe inflammation of the vaginal epithelium, accompanied with discharge, itching and abdominal pain have been reported (Krieger et al., 1990). Because of these varied symptoms and the lack of a good clinical test, diagnosis is less than adequate with approximately 50% of women misdiagnosed.

This work was supported by Public Health Service grant AI 18768 given by the National Institutes of Health. JAE was funded, in part, through NIH training grant AI 07271.

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Authors and Affiliations

  1. Department of Microbiology, The University of Texas Health Science Center, 78284-7758, San Antonio, Texas, USA

    J. A. Engbring, J. L. O’Brien & J. F. Alderete

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  1. J. A. Engbring
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  2. J. L. O’Brien
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  3. J. F. Alderete
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  1. The Hebrew University — Hadassah Medical School, Jerusalem, Israel

    Itzhak Kahane

  2. Tel Aviv University — Sackler Medical School, Tel Aviv, Israel

    Itzhak Ofek

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Engbring, J.A., O’Brien, J.L., Alderete, J.F. (1996). Trichomonas vaginalis Adhesin Proteins Display Molecular Mimicry to Metabolic Enzymes. In: Kahane, I., Ofek, I. (eds) Toward Anti-Adhesion Therapy for Microbial Diseases. Advances in Experimental Medicine and Biology, vol 408. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0415-9_25

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