The FimH Protein of Type 1 Fimbriae
The most common of the enterobacterial adhesive surface organelles, and one of the best charachterized, is type 1 fimbriae. Although the exact biological role of these organelles has been somewhat controversial, recent evidence strongly indicates that type 1 fimbriae, among other things, are implicated in enhancing the virulence of certain uropathogenic strains. A detailed dissection of the molecular biology of type 1 fimbriae and their role in bacterial adhesin would undoubtedly help to reach a clearer understanding of important aspects of bacterial pathogenesis.
KeywordsProtein Segment Surface Display System Heterologous Sequence Bacterial Adhesin Detailed Dissection
Unable to display preview. Download preview PDF.
- Klemm, P. and K.A. Krogfelt, 1994. Type 1 fimbriae of Escherichia coli. In Fimbriae, adhesion, genetics, biogenesis and vaccines.pp. 9–26. Edited by P.Klemm, CRC press, Boca Raton, Fla.Google Scholar
- Schembri, M., L. Pallesen, H. Connell, D.L. Hasty, and P. Klemm. 1996. Linker insertion analysis of the FimH adhesin of type 1 fimbriae in an Escherichia coli fimH-null background. FEMS Microbiol Lett, in press.Google Scholar