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The FimH Protein of Type 1 Fimbriae

An Adaptable Adhesin
  • Per Klemm
  • Mark Schembri
  • David L. Hasty
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 408)

Abstract

The most common of the enterobacterial adhesive surface organelles, and one of the best charachterized, is type 1 fimbriae. Although the exact biological role of these organelles has been somewhat controversial, recent evidence strongly indicates that type 1 fimbriae, among other things, are implicated in enhancing the virulence of certain uropathogenic strains. A detailed dissection of the molecular biology of type 1 fimbriae and their role in bacterial adhesin would undoubtedly help to reach a clearer understanding of important aspects of bacterial pathogenesis.

Keywords

Protein Segment Surface Display System Heterologous Sequence Bacterial Adhesin Detailed Dissection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. Klemm, P. and K.A. Krogfelt, 1994. Type 1 fimbriae of Escherichia coli. In Fimbriae, adhesion, genetics, biogenesis and vaccines.pp. 9–26. Edited by P.Klemm, CRC press, Boca Raton, Fla.Google Scholar
  2. Pallesen, L., L.K. Poulsen, G. Christiansen, and P.Klemm. 1995. Chimeric FimH adhesin of type 1 fimbriae: a bacterial surface display system for heterologous peptides. Microbiol 141: 2839–2848CrossRefGoogle Scholar
  3. Schembri, M., L. Pallesen, H. Connell, D.L. Hasty, and P. Klemm. 1996. Linker insertion analysis of the FimH adhesin of type 1 fimbriae in an Escherichia coli fimH-null background. FEMS Microbiol Lett, in press.Google Scholar
  4. Sokurenko, E. V., H.S Courtney, S.N. Abraham, P. Klemm, and D.L. Hasty. 1992. Functional heterogeneity of type 1 fimbriae of Escherichia coli. Infect. Immun 60:4709–4719.PubMedGoogle Scholar
  5. Sokurenko, E. V., H.S. Courtney, D.E. Ohman, P. Klemm, and D.L. Hasty. 1994. FimH family of type 1 fimbrial adhesins: Functional heterogeneity due to minor sequence variations among fimH genes. J.Bacteriol 176: 748–755.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Per Klemm
    • 1
  • Mark Schembri
    • 1
  • David L. Hasty
    • 2
  1. 1.Department of MicrobiologyTechnical University of DenmarkLyngbyDenmark
  2. 2.Memphis VA Medical Center MemphisMemphisUSA

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