The Effect of Respiratory Virus Infection on Expression of Cell Surface Antigens Associated with Binding of Potentially Pathogenic Bacteria
Serious secondary bacterial infection can occur following illness due to respiratory viruses and viral infections have also been suggested to be predisposing factors for bacterial meningitis [Moore et al., 1990; Cartwright et al., 1991]. Respiratory virus infection can compromise host defences against bacterial infection in a number of ways: immune suppression; diminished phagocytosis by polymorphonuclear leucocytes; local tissue injury; loss of mucociliary function and decreased bacterial clearance; formation of exudates that enhance bacterial growth; and increased bacterial binding to virus infected cells. Most investigators have studied associations of influenza virus and respiratory pathogens such as Streptococcus pneumoniae [Plotkowski et al., 1986], Staphylococcus aureus [Musher and Fainstein, 1981] and Haemophilus influenzae [Bakeletz et al., 1988; Fainstein et al.,1980].
KeywordsRespiratory Syncytial Virus Bacterial Meningitis Invasive Pneumococcal Disease Neisseria Meningitidis Bordetella Pertussis
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