Adhesion Molecules in Leukocyte Endothelial Interaction

  • Amos Etzioni
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 408)

Abstract

Neutrophils are the front line defense against most microbial pathogens. They provide a rapid, relatively nonspecific defense mechanism, after which a more long lasting, antigen-specific response is established by T and B lymphocytes. To fulfill this role successfully, the neutrophil must be able to migrate from the blood into the area of inflammation, a process which involves activation of endothelial cells and leukocyte by inflammatory stimuli, adherence to the endothelial surface at the site of inflammation, and migration through endothelium to extravascular tissue. The orchestration of these steps must by precisely regulated to ensure a rapid response to isolate and destroy the invading pathogen yet cause minimal damage to healthy tissues (Etzioni and Douglas 1993). The process of leukocyte accumulation at sites of inflammation is a dynamic one, involves multiple steps and is mediated by several families of adhesion molecules (Springer 1995). These include the Integrins, the Selectins and members of the Immunoglobulin (Ig) superfamily. Each is involved in a different phase of leukocyte emigration through the endothelium and the synchronization of their expression and function is crucial for the normal recruitment of leukocyte from the blood stream to the tissue (Etzioni 1996).

Keywords

Migration Arthritis Carbohydrate Codon Recombination 

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Amos Etzioni
    • 1
  1. 1.Department of Pediatrics and Clinical ImmunologyRambam Medical Center, Faculty of Medicine TechnionHaifaIsrael

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