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Interactions of Bacterial Adhesins with the Extracellular Matrix

  • Åsa Ljungh
  • Torkel Wadström
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 408)

Abstract

The role of microbial adhesion to epithelia in mucosa-associated infections has been recognized for a long time. The discovery by Kuusela in 197823 that Staphylococcus aureus strains specifically bind the extracellular matrix (ECM) and plasma glycoprotein fibronectin, Fn, launched a broad field of research on (i) how microbes, i.e. bacteria, parasites, fungi and viruses, interact with ECM components, and (ii) the role of interaction with these subepithelial structures in the pathogenesis of various infectious diseases30. We will here describe some of these interactions, and emphasize some possible targets for anti-adhesion therapy.

Keywords

Bacterial Adhesion Microbial Adhesion Biomaterial Surface Basement Membrane Protein Fibronectin Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Åsa Ljungh
    • 1
  • Torkel Wadström
    • 1
  1. 1.Department of Medical MicrobiologyLund UniversityLundSweden

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