Alternative Inhibitors Of Mycoplasma Adherence
Mycoplasma is the trivial name of the class Mollicutes, a group of minute wall-less bacteria comprising now more than 140 species. They are characterized by their small genome size; the smallest of bacteria. It comprises about 500-1000 predicted coding sequences (genes) as compared to, for example, 1727 and about 4000 in Hœmphilus influenza and Escherichia coli respectively. The complete genome of the smallest mycoplasma, Mycoplasma genitalium which is a human pathogen, was elucidated very recently by Fraser et al. It is 580 kb long and comprises only 470 predicted coding sequences. By evolution, the mycoplasmas belong to the gram-positive bacteria with low G+C genome. They underwent genome reduction and with it, also lost much of their biosynthetic machinery. The organisms grow in broth, but need a complex medium. It is therefore not surprising that most mycoplasmas are parasites, and many are pathogens of a vast variety of hosts, including humans. In addition, they easily contaminate the rich culture media and then adhere to the cells grown there and therefore are considered to be pests of cells in culture.
KeywordsSialic Acid Dextran Sulfate Mycoplasma Pneumoniae Sialic Acid Residue Host Cell Membrane
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