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Endogenous Opioids and HIV Infection

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AIDS, Drugs of Abuse, and the Neuroimmune Axis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 402))

Abstract

Beta endorphin enhanced the HIV-p24 production in fetal microglia infected with HIV-1 JR-CSF a strain that replicates poorly in these cells. Enhancement of HIV-p24 production by beta endorphin was associated with increased tumor necrosis factor a, interleukin-1 and IL6 production. In addition, beta endorphin activated parent HIV promoter. However, this transactivation is diminished when NFkB and SP-1 regions were deleted from HIV-LTR. These data demonstrate that beta endorphin enhances HIV-1JR-CSF replication in microglia by increased cytokine production and activation of HIV promoter possibly by NFkB and SP-1 transcription factors.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Duke Medical Center, Durham, North Carolina, USA

    Kamaraju S. Sundar Ph. D. (Director), Lakshmi S. Kamaraju, William H. Wilson & James E. Lee

  2. Eve Clinic, National Boulevard, Los Angeles, California, USA

    James McMahon & Robert A. Bitonte

  3. Department of Medicine, University of California at Irvine, California, USA

    Sastry Gollapudi

  4. Laboratory of Molecular Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Ling-yuan Kong & John S. Hong

Authors
  1. Kamaraju S. Sundar Ph. D.
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  2. Lakshmi S. Kamaraju
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  3. James McMahon
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  4. Robert A. Bitonte
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  5. Sastry Gollapudi
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  6. William H. Wilson
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  7. Ling-yuan Kong
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  8. John S. Hong
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  9. James E. Lee
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Editor information

Editors and Affiliations

  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Herman Friedman

  2. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein

  3. Emory University, Atlanta, Georgia, USA

    John Madden

  4. Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA

    Burt M. Sharp

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© 1996 Plenum Press, New York

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Sundar, K.S. et al. (1996). Endogenous Opioids and HIV Infection. In: Friedman, H., Eisenstein, T.K., Madden, J., Sharp, B.M. (eds) AIDS, Drugs of Abuse, and the Neuroimmune Axis. Advances in Experimental Medicine and Biology, vol 402. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0407-4_8

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  • DOI: https://doi.org/10.1007/978-1-4613-0407-4_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8038-2

  • Online ISBN: 978-1-4613-0407-4

  • eBook Packages: Springer Book Archive

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