Abstract
Cytokines, key participants in immune/inflammatory processes, have recently been demonstrated to play a role in neural functions. Receptors for the cytokine tumor necrosis factor (TNFα) have been localized to many regions of the brain.1 TNFα itself, along with another cytokine, interleukin-1, is contained in neuronal fibers/elements innervating various brain regions.2,3 In addition, neurons grown in vitro are able to synthesize and secrete the cytokine interleukin-1β.4 Therefore, it was of interest to determine whether fluctuations in cytokine content were associated with alterations in neuron function.
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© 1996 Springer-Verlag New York, Inc.
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Ignatowski, T.A., Noble, B.K., Wright, J.R., Gorfien, J.L., Spengler, R.N. (1996). TNFα. In: Friedman, H., Eisenstein, T.K., Madden, J., Sharp, B.M. (eds) AIDS, Drugs of Abuse, and the Neuroimmune Axis. Advances in Experimental Medicine and Biology, vol 402. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0407-4_28
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DOI: https://doi.org/10.1007/978-1-4613-0407-4_28
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