Abstract
Numerous studies have documented the altered expression of various cytokines or their genes in the brain in a variety of central nervous system (CNS) pathologic states such as multiple sclerosis (MS), acquired immunodeficiency syndrome (AIDS) encephalopathy, stroke, Alzheimer’s disease, scrapie (spongiform encephalopathy), other infectious diseases and trauma. Whether the presence of cytokines in these neuropathologic states represents a primary or secondary event and the extent to which these factors may contribute to the development and progression of clinicopathologic alterations in these disorders remains largely unknown. We have focused on these issues by utilizing a transgenic approach to direct the constitutive expression of a variety of cytokines to astrocytes in the intact CNS of mice.1–4 Transgenic expression of cytokines in the CNS of mice allows not only the investigation of complex cellular responses at a localized level in the intact brain, but also more closely recapitulates the expression of these mediators as found in pathogenetic states.
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References
Campbell, I.L., Abraham, C.R., Masliah, E., Kemper. P., Inglis, J.D., Oldstone, M.B.A. and Mucke, L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. USA. 90: 10061–10065, 1993.
Chiang, C-S., Stalder, A.S., Samimi, A. and Campbell, I.L.. Reactive gliosis as a consequence of IL-6 expression in the brain. Studies in transgenic mice. Dev Neurosci., 16: 212–221, 1994.
Campbell, I. L. Neuropathogenic actions of cytokines assessed in transgenic mice. Int. J. Dev. Neurosci., 13: 275–284, 1995.
Campbell, I. L. Neuropathogenic actions of cytokines assessed in transgenic mice. Int. J. Dev. Neurosci., 13: 275–284, 1995.
Gold, L.H., Heyser, C.J. and Campbell, I.L. Progressive cognitive impairment in discriminated avoidance performance in GFAP-IL6 transgenic mice. Neurosci. Abstr. 21: 2110, 1995.
Gold, L.H., Brot, M.D., Polis, I., Schroeder, R.S., Tishon, A., de la Torre, J-C., Oldstone. M.B.A. and Koob, G.F. Behavioral effects of persistent lymphocytic choriomeningitis virus infection in mice. Behay. Neural Biol., 62: 100–109, 1994.
Steffensen, S.C., Campbell, I.L. and Henriksen, S.J. Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice. Brain Res., 652: 149–153, 1994.
Bellinger, F.P., Madamba, S.G., Campbell, I.L. and Siggins, G.R. Reduced long-term potentiation in the dentate gyms of transgenic mice with cerebral overexpression of interleukin-6. Neurosci. Lett., 198: 95–98, 1995.
Jones, B.J. and Roberts, D.J. The quantitative measurement of motor inco-ordination in naive mice using an accelerating rota-rod. JPharrn Pharmac 20: 302–304, 1968.
Laffan, E.W., Lisciotto, C.A., Gapp, D.A. and Weldon, D.A. Development of rotorod performance in normal and congenitally hypothyroid mutant mice. Beh Neural Biol 52: 411–416, 1989.
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© 1996 Springer-Verlag New York, Inc.
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Gold, L.H. et al. (1996). Behavioral and Neurophysiological Effects of CNS Expression of Cytokines in Transgenic Mice. In: Friedman, H., Eisenstein, T.K., Madden, J., Sharp, B.M. (eds) AIDS, Drugs of Abuse, and the Neuroimmune Axis. Advances in Experimental Medicine and Biology, vol 402. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0407-4_26
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DOI: https://doi.org/10.1007/978-1-4613-0407-4_26
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