Immunopathogenesis of HIV Infection

Role of Alcohol and HIV Peptides
  • Madhavan P. N. Nair
  • Stanley A. Schwartz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 402)


We examined the in vitro effects of ethyl alcohol and a recombinant HIV-1, fusion peptide, env-gag, corresponding to portions of the gp-41 envelope (env) and internal core (gag) proteins on the natural killer (NK) cell activities of lymphocytes from healthy donors. Preculture of large granular lymphocytes (LGL) from normal donors with 0.3% alcohol for 72 hr significantly inhibited NK activity compared to untreated controls. Direct addition, without preculture, of alcohol (0.1%, 0.2% and 0.3%) and env-gag peptide (10 ng/ml) at concentrations which did not affect NK activity when either was added alone, produced a significant, synergistic, inhibitory effect on NK activity when added together. This synergis­tic effect of alcohol and HIV-derived soluble products is consistent with a model proposing that alcohol abuse may be a co-factor involved in the progression of HIV infections.


Human Immunodeficiency Virus Natural Killer Human Immunodeficiency Virus Infection Natural Killer Activity Direct Addition 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Madhavan P. N. Nair
    • 1
  • Stanley A. Schwartz
    • 1
  1. 1.Departments of Medicine and MicrobiologyState University of New York at BuffaloUSA

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