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Immunopathogenesis of HIV Infection

Role of Alcohol and HIV Peptides
  • Madhavan P. N. Nair
  • Stanley A. Schwartz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 402)

Abstract

We examined the in vitro effects of ethyl alcohol and a recombinant HIV-1, fusion peptide, env-gag, corresponding to portions of the gp-41 envelope (env) and internal core (gag) proteins on the natural killer (NK) cell activities of lymphocytes from healthy donors. Preculture of large granular lymphocytes (LGL) from normal donors with 0.3% alcohol for 72 hr significantly inhibited NK activity compared to untreated controls. Direct addition, without preculture, of alcohol (0.1%, 0.2% and 0.3%) and env-gag peptide (10 ng/ml) at concentrations which did not affect NK activity when either was added alone, produced a significant, synergistic, inhibitory effect on NK activity when added together. This synergis­tic effect of alcohol and HIV-derived soluble products is consistent with a model proposing that alcohol abuse may be a co-factor involved in the progression of HIV infections.

Keywords

Human Immunodeficiency Virus Natural Killer Human Immunodeficiency Virus Infection Natural Killer Activity Direct Addition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Madhavan P. N. Nair
    • 1
  • Stanley A. Schwartz
    • 1
  1. 1.Departments of Medicine and MicrobiologyState University of New York at BuffaloUSA

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