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Plant Phenolics as Potential Cancer Prevention Agents

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Dietary Phytochemicals in Cancer Prevention and Treatment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 401))

Abstract

The frequent consumption of fresh fruits and vegetables is associated with a lower cancer incidence in humans, and in experimental carcinogenesis. There are several groups of substances in plant foods which may contribute to this inhibition of tumor development. Almost all fresh fruits, vegetables and cereal grains contain appreciable amounts of naturally occurring plant phenolics. A brief overview will be presented of the most common plant phenolics in human foods and their chemical and biochemical properties. Plant phenolics, originally hypothesized to inhibit mutagenesis and/or carcinogenesis by virtue of antioxidant or electrophile trapping mechanisms, can also act as potent modulators of arachidonic metabolism cascade pathways. Certain plant phenols can be effective inhibitors of chemical mutagens, in vitro, and/or carcinogenesis in vivo. The historical origins, hypotheses of actions, current status and potential adverse effects of the utility of plant phenolics to reduce risk of cancer are discussed, as well as future possibilities and needs and objectives for future research.

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References

  1. Wattenberg LW. Chemoprevention of cancer. Cancer Res, 1985, 45, 1–8.

    Article  CAS  Google Scholar 

  2. Wattenberg LW. Inhibition of carcinogenesis by minor anutrient constituents of the diet. Proc of the Nutrition Soc, 1990, 49, 173–183.

    Article  CAS  Google Scholar 

  3. Hartman PE and Shankel DM. Antimutagens and anticarcinogens: a survey of putative interceptor molecules. Env and Mol Mutagenesis, 1990, 15, 145–182.

    Article  CAS  Google Scholar 

  4. Harborne JB. in Methods in Plant Biochemistry, Vol. I: Plant Phenolics; Harborne JB, Ed; Academic Press: London, UK, 1989, 1–28.

    Google Scholar 

  5. Van Straten S. Volatile compounds in food; Central Institute for Nutrition and Food Research: Zeist, The Netherlands, 1977.

    Google Scholar 

  6. Van Sumere CF. in Methods in Plant Biochemistry. Vol I: Plant Phenolics; Harborne JB, ed; Academic Press: London, UK, 1989, 29–73.

    Google Scholar 

  7. Nishimura H, Nonaka GI, Nishioaka I. Seven quinic acid gallates from quercus stenophylla. Phytochem. 1984, 23, 2621–2623.

    Article  CAS  Google Scholar 

  8. Herrman K. Occurrence and content of hydroxycinnamic and hydroxybenzoic acid compounds in foods. CRC Crit Rev Food Sci Nutri, 1989. 28, 315–347.

    Article  Google Scholar 

  9. Eskin NAM. Biochemistry of Foods; Academic Press: San Diego, CA 1990, 401–432.

    Google Scholar 

  10. Haslam E. Plant Polyphenols: Cambridge University Press: Cambridge, UK. 1989.

    Google Scholar 

  11. Harborne JB. Comparative Biochemistry of the Flavonoids; Academic Press: London, 1967.

    Google Scholar 

  12. Harborne JB and Mabry TJ. The Flavonoids: Advances in Research; Chapman and Hall: London, UK, 1982.

    Google Scholar 

  13. Harborne JB, Mabry TJ. The Flavonoids: Advances in Research Since 1980; Chapman and Hall: London, UK, 1988, Vol. 2.

    Google Scholar 

  14. Markham KR. In Methods in Plant Biochemistry, Vol I: Plant Phenolics, Harborne JB, Ed; Academic Press: London, UK, 1989, 197–235.

    Google Scholar 

  15. Wattenberg LW, Coccia JB, Lam LKT. Inhibitory effects of phenolic compounds on benzo(a)pyrene induced neoplasia. Cancer Res, 1990, 40, 2820–2823.

    Google Scholar 

  16. Newmark HL and Mergens WJ. α-Tocopherol (Vitamin E) and its relationship to tumor induction and development, in: Inhibition of Tumor Induction and Development; Zedek MS and Lipkin M. eds. Plenum Press, New York, NY 1981, 127–168.

    Google Scholar 

  17. Kuenzig W, Chang J, Norkus E, Holowaschenko H, Newmark HL, Mergens W and Conney AH. Caffeic and ferulic acid as blockers of nitrosamine formation. Carcinogenesis, 1984, 5: 309–313.

    Article  CAS  Google Scholar 

  18. Newmark HL. A hypothesis for dietary components as blocking agents of chemical carcinogenesis: plant phenolics and pyrrole pigments. Nutrition and Cancer, 1984, 6: 58–70.

    Article  CAS  Google Scholar 

  19. Newmark HL. Plant phenolics as inhibitors of mutational and precarcinogenic events. Can J Physiol Pharmacol, 1987, 65: 461–466.

    Article  CAS  Google Scholar 

  20. Dewhirst FE. Structure-activity relationships for inhibition of prostaglandin cyclooxygenase by phenolic compounds. Prostaglandins, 1980, 20: 209–222.

    Article  CAS  Google Scholar 

  21. Nakadate T, Yamamoto S, Ishu M, Kato R. Inhibition of 0-tetradecanoylphorbol-13-acetate induced epidermal ornithine decarboxylase by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway. Carcinogenesis, 1982, 3: 1411–1414.

    Article  CAS  Google Scholar 

  22. Karmali RA. Lipid nutrition, prostaglandins and cancer, in: Biochemistry of Arachidonic Acid Metabolism; Lands EM, Ed: Martinas Nijhoff Publishing: Boston, MA, 203–212.

    Google Scholar 

  23. Katiyar S, Agarwal R, Wood GS et al. Inhibition of 12-0-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7, 12-dimethylbenz(a)anthracene-initiated SENCAR mouse skin by a polyphenols fraction isolated from green tea. Cancer Res, 1992, 52: 6890–6897.

    CAS  Google Scholar 

  24. Deschner EE, Ruperto J, Wong G, Newmark HL. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis, 1991, 12: 1193–1196.

    Article  CAS  Google Scholar 

  25. Huang MT, Lou YR, Ma W, Newmark HL, Reuhl KR, Conney AH. Inhibitory effects of dietary curcumin on forestomach, duodenal and colon carcinogensis in mice. Cancer Research, 1994, 54: 5841–5847.

    CAS  Google Scholar 

  26. Schwartz B, Fraser GM, Levy J, Sharoni Y, Guberman R, Krawiec J, Lamprecht SA. Differential distribution of protein kinases along the crypt-to-lumen regions of rat colonic epithelium. Gut, 1988, 29, 1213–1221.

    Article  CAS  Google Scholar 

  27. Kato R, Nakadate T, Yamamoto S, Sugimura T. Inhibition of 12-0-tetradecanoylphorbol-13-acetate induced tumor promotion and ornithine decarboxylase activty by quercetin: possible involvement by lipoxygenase inhibition. Carcinogenesis, 1983, 4: 1301–1305.

    Article  CAS  Google Scholar 

  28. Verma AK, Johnson JA, Gould MN, Tanner MA. Inhibition of 7, 12-dimethylbenz(a)anthracene and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin. Cancer Res, 1988, 48, 5754–5758.

    CAS  Google Scholar 

  29. Deschner EE, Ruperto JF, Wong GY, Newmark HL. The effect of dietary quercetin and rutin on AOM-induced acute colonic epithelial abnormalities in mice fed a high-fat diet. Nutrition and Cancer, 1993, 20: 199–204.

    Article  CAS  Google Scholar 

  30. Huang MT, Robertson FM, Lysz T, Ferraro T, Wang ZY, Georgiadis CA, Laskin JD, Conney AH. Inhibitory effects of curcumin on carcinogenesis in mouse epidermis, in: MT Huang, CT Ho, CY Lee. (eds) Phenolic Compounds in Food and Their Effects on Health II: 1992. Antioxidants and Cancer Prevention Society, 339–349, Washington DC: American Chemical Society.

    Google Scholar 

  31. Tanaka T, Yoshima N, Sugie S, Mori H. Protective effects against liver, colon and tongue carcinogenesis by plant phenols. In: MT Huang, CT Ho, and CY Lee (Eds). Phenolic Compounds in Food and Their Effects on Health II: Antioxidants and Cancer Prevention, pp. 326–337. Washington DC: American Chemical Society, 1192.

    Google Scholar 

  32. Lesca P. Protective effects of ellagic acid and other plant phenols on benzo(a)pyrene-induced neoplasia in mice. Carcinogenesis, 1983, 6: 1651–1653.

    Article  Google Scholar 

  33. Mandal S, Stoner GD. Inhibition of methylbenzylnitrosamine-induced esophageal tumors in rats by ellagic acid. Carcinogenesis, 1990, 11: 55–61.

    Article  CAS  Google Scholar 

  34. Hirose M, Fukushima S, Shirai T, Hasegawa R, Kato T, Tanaka H, Asakawa E, and Ito N. Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice. 1990. Jpn J Cancer Res, 81: 207–212, 1990.

    CAS  Google Scholar 

  35. Hanham AF, Dunn BP, Stich HF. Clastogenic activity of caffeic acid and its relationship to hydrogen peroxide generated during antooxidation. Mutation Res, 1982, 116, 333–339.

    Google Scholar 

  36. Aldercreutz M. Western diet and western diseases: some hormonal and biochemical mechanisms and associations. Scand J Lab Invest, 1990, 50, Suppl 201, 3–23.

    Article  Google Scholar 

  37. Horwitz C, Walker APR. Lignans — additional benefits from fiber? Nutr Cancer, 1984, 6: 73–76.

    Article  CAS  Google Scholar 

  38. Serraino M, Thompson LU. The effect of flaxseed supplementation on the initiation and promotional stages of mammary carcinogenesis. Nutr Cancer, 1992, 17: 153–159.

    Article  CAS  Google Scholar 

  39. Verma AK. Modulation of mouse skin carcinogenesis and epidermal phospholipid biosynthesis by the flavonol quercetin. In: MT Huang, CT Ho and CY Lee (Eds) Phenolic Compounds in Food and Their Effects on Health II: Antioxidants and Cancer Prevention, pp. 350–364. Washington DC. American Chemical Society, 1992.

    Google Scholar 

  40. Gugler R, Leschick M, Dengler HJ. Disposition of quercetin in man after single oral and intravenous doses. Europ J Clin Pharmacol, 1975, 9: 229–234.

    Article  CAS  Google Scholar 

  41. Jacobson EA, Newmark HL, Baptista J, Bruce WR. A preliminary investigation of the metabolism of dietary phenolics in humans. Nutr Reports Intern, 1983, 28: 1409–1417.

    CAS  Google Scholar 

  42. Smith TJ and Yang CS. Effects of food phytochemicals on xenobiotic metabolism and tumorigenesis. In: Food Phytochemicals for Cancer Prevention I. (Huang M-T, Osawa T, Ho C-T, Rosen RT, eds.) pp. 17–48, ACS Symposium Series 546, Washington, DC, Chapter 2, 1994.

    Google Scholar 

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Authors and Affiliations

  1. Memorial Sloan Kettering Cancer Center, New York, New York, 10021, USA

    Harold L. Newmark

  2. Rutgers University, Piscataway, New Jersey, 08855-0789, USA

    Harold L. Newmark

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  1. Harold L. Newmark
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    © 1996 Plenum Press, New York

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    Newmark, H.L. (1996). Plant Phenolics as Potential Cancer Prevention Agents. In: Dietary Phytochemicals in Cancer Prevention and Treatment. Advances in Experimental Medicine and Biology, vol 401. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0399-2_3

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    • DOI: https://doi.org/10.1007/978-1-4613-0399-2_3

    • Publisher Name: Springer, Boston, MA

    • Print ISBN: 978-1-4613-8034-4

    • Online ISBN: 978-1-4613-0399-2

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