Skip to main content
SpringerLink
Log in

Wheat Bran, Colon Cancer, and Breast Cancer

What Do We Have? What Do We Need?

  • Chapter
Dietary Phytochemicals in Cancer Prevention and Treatment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 401))

Abstract

“Health maintenance is the key not only to human health, but to human culture’s economic sustenance, and the human diet is central to health maintenance.”1

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hendrich S, Lee KW, Xu X, Wang HJ, MurphyPA. Defining food components as new nutrients J Nutr 1994 124:1789S–1792S.

    Google Scholar 

  2. Thompson LU. Antioxidants and hormone-mediated health benefits of whole grains. Critical Reviews in Food Science and Nutrition 1994 34: 473–497.

    Article  CAS  Google Scholar 

  3. Thompson LU. Potential health benefits and problems associated with antinutrients in foods. Food Research Internl 1993; 26:131–149.

    Article  CAS  Google Scholar 

  4. American Cancer Society. Cancer facts and figures. New York, 4–8. (1990).

    Google Scholar 

  5. Vargas PA, Alberts DS. Primary prevention of colorectal cancer through dietary modification. Cancer 1992;70:1229–1235.

    Article  CAS  Google Scholar 

  6. Greenwald P, Lanza E, Eddy GA. Dietary fiber in the reduction of colon cancer risk. J Am Diet Assoc 1987 87:1178–1188.

    CAS  Google Scholar 

  7. Alberts DS, Einspahr J, Rees-McGee S, Ramanujam P, Buller MK, Clark L, Ritenbaugh C, Atwood J, Pethigal P, Earnest D, Villar H, Phelps J, Lipkin M, Wargovich M, Meyskens, FL Jr. Effects of dietary wheat bran fiber on rectal epithelial cell proliferation in patients with resection for colorectal cancers. J Natl Cancer Inst. 1990; 82:1280–1285.

    Article  CAS  Google Scholar 

  8. Ho EE, Atwood JR, Benedict J, Ritenbaugh C, Sheehan ET, Ambrams C, Alberts DS, Meyskens FL Jr. A community-based feasibility study using wheat bran fiber supplementation to lower colon cancer risk. Preventive Medicine 1991 20, 213–225.

    Article  CAS  Google Scholar 

  9. Witkin R, Greenwald KM. Familial adenomatous polyposis: a nutritional intervention trial. J Natl Cancer Inst 1989 81:1272–1273.

    Article  Google Scholar 

  10. Alabaster O, Tang ZC, Frost A, Shivapurkar N. Potential synergism between wheat bran and psyllium; enhanced inhibition of colon cancer. Cancer Letters 1993 75 53–58.

    Article  CAS  Google Scholar 

  11. Boffa LC, Lupton JR, Mariani MR, Ceppi M, Newmark HL, Scalmati A, Lipkin M. Modulation of colonic epithelial cell proliferation, histone acetylation, and luminal short chain fatty acids by variation of dietary fiber (wheat bran) in rats. Cancer Research, 1992 52:5906–5912.

    CAS  Google Scholar 

  12. Mclntyre A, Gibson PR, Young GR Butyrate production from dietary fiber and protection against large bowel cancer in a rat model. Gut 1993; 34:386–391.

    Article  Google Scholar 

  13. Candido EP, Reeves R, Davies JR. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 1978 14: 105–13.

    Article  CAS  Google Scholar 

  14. Reddy B, Engle A, Katsifis S, Simi B, Bartram HP, Perrino P, Mahan C. Biochemical epidemiology of colon cancer: effect of types of dietary fiber on fecal mutagens, acid, and neutral sterols in healthy subjects. Cancer Res 1989; 49:4629–35.

    CAS  Google Scholar 

  15. Kritchevsky D. Fiber steroids and cancer. Cancer Res 1983; 43:2491S–2495S.

    CAS  Google Scholar 

  16. Kritchevsky D. Fiber and cancer. In: Vahoun GV, Kritchevsky D. Eds. Dietary Fiber: Basic and Clinical Aspects, Plenum, New York, 1986: 427–432.

    Google Scholar 

  17. Klurfeld DM. Dietary fiber-mediated mechanisms in carcinogenesis. Cancer Research, 1992 52.2055s–2059s.

    CAS  Google Scholar 

  18. Rose DP. Dietary factors and breast cancer. Cancer Surv 1986 5:671–87.

    CAS  Google Scholar 

  19. Weisburger JH, Kroes R. Mechanisms in nutrition and cancer. Euro J Cancer Prevent, 1994 3:293–298.

    Article  CAS  Google Scholar 

  20. Willett WC, Hunter DJ, Stampfer MJ, Colditz G, Manson JA, Spiegelman D, Rosner B, Hennekens CH, Speizer FE. Dietary fat and fiber in relation to risk of breast cancer: An 8 year follow-up. JAMA 1992 268:2037–2044.

    Article  Google Scholar 

  21. Jones LA, Ota DM, Jackson GA, Jackson PM, Kemp K, Anderson DE, McCamant SK, Bauman DH. Bioavailability of estradiol as a marker for breast cancer risk assessment. Cancer Res 1987 47:5224–5229.

    CAS  Google Scholar 

  22. Langley MS, Hammon GL, Bardsley A, Sellwood RA, Anderson DC Serum steriod binding proteins and the bioavailability of estradiol in relation to breast diseases. J Natl Cancer Inst 1985 75:823–829.

    CAS  Google Scholar 

  23. Ota DM, Jones LA, Jackson GL, Jackson PM, Kemp K, Bauman D. Obesity, non-protein-bound estradiol levels, and distribution of estradiol in the sera of breast cancer patients. Cancer 1986 57:558–62.

    Article  CAS  Google Scholar 

  24. Nandi S, Guzman RC, Yang J. Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis. Proc. Natl. Acad. Sci. USA 1995 92:3650–3657.

    Article  CAS  Google Scholar 

  25. Goldin BR, Gorbach SL. Effect of diet on the plasma levels, metabolism, and excretion of estrogens. Am J Clin Nutr 1988 48:787–790.

    CAS  Google Scholar 

  26. Rose DP, Goldman M, Connolly JM, Strong LE. High-fiber diet reduces serum estrogen concentrations in premenopausal women. Am J Clin Nutr 1991 54: 520–525.

    CAS  Google Scholar 

  27. Goldin BR, Woods MN, Spiegelman DL, Longcope C, Morrill-LaBrode A, Dwyer JT, Gualtieri LJ, Hertzmark E, Gorbach SL. The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions. Cancer, 1994 74:1125–1131.

    Article  CAS  Google Scholar 

  28. Gorbach SL, Golden BR. Diet and the excretion and enterohepatic cycling of estrogens. Preventive Medicine 1987 16:525–531.

    Article  CAS  Google Scholar 

  29. Heber D, Ashley JM, Leaf DA, Barnard RJ. Reduction of serum estradiol in postmenopausal women given free access to low-fat high-carbohydrate diet. Nutrition 1991 7:137–140.

    CAS  Google Scholar 

  30. Rose DP. Dietary fiber, phytoestrogens, and breast cancer. Nutrition 1992 8: 47–51.

    CAS  Google Scholar 

  31. Cohen, LA, Kendall ME, Zang E, Meschter C, Rose DP. Modulation of N-nitrosomethylurea-induced mammary tumor promotion by dietary fiber and fat. J Natl Cancer Inst 1991 83:496–501.

    Article  CAS  Google Scholar 

  32. Arts CJM, Albert TH, De Bie HJ, Van Den Berg H, Van’t Veer P, Bunnik GSJ, Thijssen JSH. Influence of wheat bran on NMU-induced mammary tumor development, plasma estrogen levels and estrogen excretion in female rats. J Steroid Biochem. Molec. Biol. 1991 39:193–202.

    Article  CAS  Google Scholar 

  33. Gorbach SL, Estrogens, breast cancer, and intestinal flora. Rev Infect Dis. 1984 6:S85–90.

    Article  Google Scholar 

  34. Arts CJM, Govers CARL, Van Den Berg H, Wolters MGE, Van Leeuwen P, Thussen JHH. In vitro binding of estrogens by dietary fiber and the in vivo apparent digestibility tested in pigs. J Steroid Biochem. Molec. Biol 1991 38:621–628.

    Article  CAS  Google Scholar 

  35. Baghurst PA, Rohan TE. High-fiber diets and reduced risk of breast cancer. Int. J Cancer 1994; 56:173–176.

    Article  CAS  Google Scholar 

  36. Toniolo PG, Levitz M, Zeleniuch-Jacquotte A, Banerjee S, Koenig KL, Shore RE, Strax P, Pasternack BS. A prospective study of endogenous estrogens and breast cancer in postmenopausal women. J Natl Cancer Inst 1995; 87:190–197.

    Article  CAS  Google Scholar 

  37. Shamsuddin AM. Inositol Phosphates have novel anticancer function. J Nutr. 1995 125: 725S–732S.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kellogg Canada Inc., Toronto, Ontario, Canada

    Richard M. Black

  2. Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

    Richard M. Black

Authors
  1. Richard M. Black
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

    Rights and permissions

    Reprints and permissions

    Copyright information

    © 1996 Plenum Press, New York

    About this chapter

    Cite this chapter

    Black, R.M. (1996). Wheat Bran, Colon Cancer, and Breast Cancer. In: Dietary Phytochemicals in Cancer Prevention and Treatment. Advances in Experimental Medicine and Biology, vol 401. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0399-2_20

    Download citation

    • DOI: https://doi.org/10.1007/978-1-4613-0399-2_20

    • Publisher Name: Springer, Boston, MA

    • Print ISBN: 978-1-4613-8034-4

    • Online ISBN: 978-1-4613-0399-2

    • eBook Packages: Springer Book Archive

    Publish with us

    Policies and ethics

    Search

    Navigation