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Molecular Findings and Classification of Malignant Lymphomas

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Molecular Biology of Hematopoiesis 5

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Summary

The Authors review the problem of lymphoma classification in the light of the Revised European-American Lymphoma (R.E.A.L.) scheme, recently proposed by the International Lymphoma Study Group (ILSG). In particular, the R.E.A.L. Classification is a list of clinico-pathologic entities, all well known from the literature, which the ILSG members agreeded on. Although it contains nothing new, for the first time it organically reports all the elements - including immunophenotype and molecular data - which characterize a given lymphoma entity. This approach corresponds to the need of objective criteria, which integrate the often puzzling morphologic findings. Furthermore, a better knowledge on the molecular events which contribute to tumour development and progression, is of paramount importance for the identification of more specific and successful therapies. Some relevant molecular findings included in the Classification and additional data obtained by the ILSG members following its publication are discussed.

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Author information

Authors and Affiliations

  1. Second Service of Pathologic Anatomy Unit of Haematopathology, Bologna University, School of Medicine S. Orsola Hospital, Bologna, Italy

    Professor Stefano A. Pileri (Direttore del Secondo Servizio di Anatomia Patologica - Sezione di Istologia Emolinfopatologica), Claudio Ceccarelli, Elena Sabattini, Donatella Santini, Ornella Leone & Stefania Damiani

  2. Policlinico S. Orsola, Via Massarenti 9, 40138, Bologna, Italy

    Professor Stefano A. Pileri (Direttore del Secondo Servizio di Anatomia Patologica - Sezione di Istologia Emolinfopatologica)

  3. Institute of Pathologic Anatomy, Siena University, School of Medicine Le Scotte Hospital, Siena, Italy

    Lorenzo Leoncini

  4. Institute of Haematology, Haematopathology Laboratory, Perugia University, School of Medicine Monteluce Hospital, Perugia, Italy

    Brunangelo Falini

Authors
  1. Professor Stefano A. Pileri
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  2. Claudio Ceccarelli
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  3. Elena Sabattini
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  4. Donatella Santini
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  5. Ornella Leone
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  6. Stefania Damiani
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  7. Lorenzo Leoncini
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  8. Brunangelo Falini
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Editor information

Editors and Affiliations

  1. The Rockefeller University, New York, New York, USA

    Nader G. Abraham

  2. University of Tokyo, Tokyo, Japan

    Shigetaka Asano

  3. Universität-Gesamthoschschule Essen, Essen, Germany

    Günther Brittinger

  4. Istituto Cantonale di Patologia, Locarno, Switzerland

    Georges J. M. Maestroni

  5. Western Pennsylvania Cancer Institute, Pittsburgh, Pennsylvania, USA

    Richard K. Shadduck

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© 1996 Plenum Press, New York

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Pileri, S.A. et al. (1996). Molecular Findings and Classification of Malignant Lymphomas. In: Abraham, N.G., Asano, S., Brittinger, G., Maestroni, G.J.M., Shadduck, R.K. (eds) Molecular Biology of Hematopoiesis 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0391-6_18

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  • DOI: https://doi.org/10.1007/978-1-4613-0391-6_18

  • Publisher Name: Springer, Boston, MA

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