The Biology of Vascular Endothelial Growth Factor

  • Napoleone Ferrara
Part of the NATO ASI Series book series (NSSA, volume 285)


The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1. Neovascularization (angiogenesis) is also implicated in the pathogenesis of a number of disorders. These include: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis1,2. A strong correlation has been noted between density of microvessels in primary breast cancers and their nodal metastases and patient survival3. Similarly, a correlation has been reported between vascularity and invasive behavior in several other tumors4–6.


Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor Receptor Vascular Endothelial Growth Factor Expression Proliferative Diabetic Retinopathy Bullous Pemphigoid 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Napoleone Ferrara
    • 1
  1. 1.Department of Cardiovascular ResearchGenentech, Inc.South San FranciscoUSA

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