The Biology of Vascular Endothelial Growth Factor

  • Napoleone Ferrara
Part of the NATO ASI Series book series (NSSA, volume 285)

Abstract

The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1. Neovascularization (angiogenesis) is also implicated in the pathogenesis of a number of disorders. These include: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis1,2. A strong correlation has been noted between density of microvessels in primary breast cancers and their nodal metastases and patient survival3. Similarly, a correlation has been reported between vascularity and invasive behavior in several other tumors4–6.

Keywords

Ischemia Tyrosine Heparin Retina Degenerative Joint Disease 

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Napoleone Ferrara
    • 1
  1. 1.Department of Cardiovascular ResearchGenentech, Inc.South San FranciscoUSA

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