Tumor Oxygenation and Tumor Vascularity: Evidence for Their Clinical Relevance in Cancer of the Uterine Cervix and Considerations on Their Potential Biological Role in Tumor Progression

  • Michael Höckel
  • Karlheinz Schienger
  • Margarete Mitze
Part of the NATO ASI Series book series (NSSA, volume 285)

Abstract

Most solid malignancies are thought to be derived from a single neoplastic precursor cell having lost proliferation control and gained the ability to penetrate basement membranes and to invade into the stroma. During the disease course tumors increase their overall cell number by local expansion and the development of regional and distant metastases. Along with the increase in cell number the tumors loose hormonal or other external signal dependencies and acquire resistances towards radio— and chemotherapy. The progressing disease causes symptoms through impaired tissue/organ functions and complications, and finally kills the individual (unless other causes leading to death become manifest earlier).

Keywords

Permeability Migration Hydroxyl Oncol Paraffin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brown, L.F., Berse, B., Jackman, R.W., Tognazzi, K., Manseau, E.J., Dvorak, H.F., and Senger, D.R., 1993, Increased expression of vascular permeability factor (VEGF) and its receptor in kidney and bladder carcinomas, Am. J. Pathol. 143:1255.PubMedGoogle Scholar
  2. Drescher, E.E., and Gray, L.H., 1959, Influence of oxygen tension on X-ray induced damage in Ehrlich ascites tumor cells irradiated in vitro and in vivo, Radiol. Res. 11:115.CrossRefGoogle Scholar
  3. Elias, H., Henning, A., and Schwartz, D.E., 1971, Stereology: Applications to biomedical research, Histological Reviews 51:158.Google Scholar
  4. Giaccia, A.J., and Graeber, T.G., 1995, Regulation of cell proliferation by hypoxia, 43rd Annual Meeting of the Radiation Research Society, USA (1. April - 6. April 1995).Google Scholar
  5. Gray, L.H., Conger, A.D., Ebert, M., Hornsey, S., and Scott, O.C.A., 1953, The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy, Br. J. Radiol. 26:638.PubMedCrossRefGoogle Scholar
  6. Hall, E., 1994, Radiosensitivity and cell age in the mitotic cycle, in: Radiobiology for the Radiologist, J.B. Lippincott Company, Philadelphia, Pennsylvania, USA.Google Scholar
  7. Heppner, G.H., 1984, Tumor heterogeneity, Cancer Res. 44:2259.PubMedGoogle Scholar
  8. Hlatky, L., Tsionou, C, Hahnfeldt, P., and Coleman, N., 1994, Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression, Cancer Res. 54:6083.PubMedGoogle Scholar
  9. Höckel, M., Schlenger, K., Knoop, C, and Vaupel, P., 1991, Oxygenation of carcinomas of the uterine cervix: Evaluation by computerized O2 tension measurements, Cancer Res. 51:6098.PubMedGoogle Scholar
  10. Höckel, M., Knoop, C, Schlenger, K., Vorndran, B., Mitze, M., Knapstein, P.G., and Vaupel, P., 1993, Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix, Radiother. Oncol. 26:45.PubMedCrossRefGoogle Scholar
  11. Höckel, M., Vorndran, B., Schlenger, K., Baußmann, E., Knapstein, P.G., and Vaupel, P., 1993, Tumor oxygenation: A new predictive parameter in locally advanced cancer of the uterine cervix, Gynecol. Oncol. 51:141.PubMedCrossRefGoogle Scholar
  12. Malins, D.C., Holmes, E.H., Polissar, N.L., and Gunselman, S.J., 1993, The etiology of breast cancer: Characteristic alterations in hydroxyl radical-induced DNA base lesions during oncogenesis with potential for evaluating incidence risk, Cancer 71:3036.PubMedCrossRefGoogle Scholar
  13. Malins, D.C., Polissar, N.L., Nishikida, K., Holmes, E.H., Gardner, H.S., and Gunselman, S.J., 1995, The etiology and prediction of breast cancer, Cancer 75:503.PubMedCrossRefGoogle Scholar
  14. McCord, J.M., 1985, Oxygen-derived free radicals in post-ischemic tissue injury, N. Engl. J. Med. 312:159.PubMedCrossRefGoogle Scholar
  15. Nowell, P.C., 1976, The clonal evolution of tumor cell populations, Science 194:23.PubMedCrossRefGoogle Scholar
  16. O’Dwyer, P.J., Filali, M., Hamilton, T.C., and Yao, K-S, 1995, Mechanisms of altered gene expression under hypoxic conditions, 43rd Annual Meeting of the Radiation Research Society, USA (1. April - 6. April 1995).Google Scholar
  17. Plate, K.H., Breier, G., Weich, H.A., and Risau, W., 1992, Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo, Nature 359:845.PubMedCrossRefGoogle Scholar
  18. Rice, G.C., Hoy, C, and Schimke, R.T., 1986, Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells, Proc. Natl. Acad. Sci. USA 83:5978.PubMedCrossRefGoogle Scholar
  19. Russel, R.C., Roth, A.C., Kucan, J.O., and Zook, E.G., 1989, Reperfusion injury and oxygen free radicals, a review, J. Reconstr. Microsurg. 5:79.CrossRefGoogle Scholar
  20. Schimke, R.T., 1984, Gene amplification, drug resistance, and cancer, Cancer Res. 44:1735.PubMedGoogle Scholar
  21. Schlenger, K., Höckel, M., Mitze, M., Schäffer, U., Weikel, W., Knapstein, P.G., and Lambert, A., 1995, Tumor vascularity — A novel prognostic factor in advanced cervical carcinoma, Gyn. Oncol, in press:Google Scholar
  22. Shweiki, D., Itin, A., Soffer, D., and Keshet, E., 1992, Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis, Nature 359:843.PubMedCrossRefGoogle Scholar
  23. Weibel, E.R., 1969, Stereological principles for morphometry in electron microscopic cytology, Int. Rev. Cytol. 26:235.PubMedCrossRefGoogle Scholar
  24. Wright, S., 1982, The shifting balance theory and macroevolution., Annu. Rev. Genet. 16:1PubMedCrossRefGoogle Scholar
  25. Young, S.D., Marshall, R.S., and Hill, R.P., 1988, Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells, Proc. Natl. Acad. Sci. USA 85:9533.PubMedCrossRefGoogle Scholar
  26. Young, S.D., Marshall, R.S., and Hill, R.P., 1988, Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells, Proc. Natl. Acad. Sci. USA 85:9533.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Michael Höckel
    • 1
  • Karlheinz Schienger
    • 1
  • Margarete Mitze
    • 2
  1. 1.Department of Obstetrics and GynecologyUniversity of MainzMainzGermany
  2. 2.Department of PathologyUniversity of MainzMainzGermany

Personalised recommendations