Tumor Oxygenation and Tumor Vascularity: Evidence for Their Clinical Relevance in Cancer of the Uterine Cervix and Considerations on Their Potential Biological Role in Tumor Progression
Most solid malignancies are thought to be derived from a single neoplastic precursor cell having lost proliferation control and gained the ability to penetrate basement membranes and to invade into the stroma. During the disease course tumors increase their overall cell number by local expansion and the development of regional and distant metastases. Along with the increase in cell number the tumors loose hormonal or other external signal dependencies and acquire resistances towards radio— and chemotherapy. The progressing disease causes symptoms through impaired tissue/organ functions and complications, and finally kills the individual (unless other causes leading to death become manifest earlier).
KeywordsCervical Cancer Tumor Vascularity Uterine Cervix Advanced Cervical Cancer Tumor Control Probability
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- Elias, H., Henning, A., and Schwartz, D.E., 1971, Stereology: Applications to biomedical research, Histological Reviews 51:158.Google Scholar
- Giaccia, A.J., and Graeber, T.G., 1995, Regulation of cell proliferation by hypoxia, 43rd Annual Meeting of the Radiation Research Society, USA (1. April - 6. April 1995).Google Scholar
- Hall, E., 1994, Radiosensitivity and cell age in the mitotic cycle, in: Radiobiology for the Radiologist, J.B. Lippincott Company, Philadelphia, Pennsylvania, USA.Google Scholar
- O’Dwyer, P.J., Filali, M., Hamilton, T.C., and Yao, K-S, 1995, Mechanisms of altered gene expression under hypoxic conditions, 43rd Annual Meeting of the Radiation Research Society, USA (1. April - 6. April 1995).Google Scholar
- Schlenger, K., Höckel, M., Mitze, M., Schäffer, U., Weikel, W., Knapstein, P.G., and Lambert, A., 1995, Tumor vascularity — A novel prognostic factor in advanced cervical carcinoma, Gyn. Oncol, in press:Google Scholar