Tumor Oxygenation and Tumor Vascularity: Evidence for Their Clinical Relevance in Cancer of the Uterine Cervix and Considerations on Their Potential Biological Role in Tumor Progression

  • Michael Höckel
  • Karlheinz Schienger
  • Margarete Mitze
Part of the NATO ASI Series book series (NSSA, volume 285)


Most solid malignancies are thought to be derived from a single neoplastic precursor cell having lost proliferation control and gained the ability to penetrate basement membranes and to invade into the stroma. During the disease course tumors increase their overall cell number by local expansion and the development of regional and distant metastases. Along with the increase in cell number the tumors loose hormonal or other external signal dependencies and acquire resistances towards radio— and chemotherapy. The progressing disease causes symptoms through impaired tissue/organ functions and complications, and finally kills the individual (unless other causes leading to death become manifest earlier).


Cervical Cancer Tumor Vascularity Uterine Cervix Advanced Cervical Cancer Tumor Control Probability 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Michael Höckel
    • 1
  • Karlheinz Schienger
    • 1
  • Margarete Mitze
    • 2
  1. 1.Department of Obstetrics and GynecologyUniversity of MainzMainzGermany
  2. 2.Department of PathologyUniversity of MainzMainzGermany

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