NMR Structural Studies of Flexible Molecules

  • Peter E. Wright
  • H. Jane Dyson

Abstract

In recent years, NMR has been applied with great success to determine precise three- dimensional solution structures of compact globular proteins and small, inflexible cyclic peptides. NMR also holds promise for providing structural information on flexible biomolecules, although a quantitative description of structure is complicated by the inevitable population-weighted averaging of the key NMR parameters. Here we describe simple procedures for calculation of the dominant structure in the conformational ensemble of a linear peptide and for characterizing the domain motions and overall structural preferences of multidomain proteins.

Keywords

Zinc Anisotropy Proline Polypeptide Macromolecule 

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Peter E. Wright
    • 1
  • H. Jane Dyson
    • 1
  1. 1.Department of Molecular BiologyThe Scripps Research InstituteLa JollaUSA

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