The Effects of Peripheral Serotonin2 Receptor Agonist on Food Intake of Rats

  • J. Yamada
  • Y. Sugimoto
  • T. Yoshikawa
  • T. Noma
  • K. Horisaka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 398)

Abstract

It has been reported that the serotonin2 (5-HT2) receptor is involved in several physiological effects of 5-HT such as platelet aggregation and hypertension (Fozard, 1989). It has been suggested that 5-HT participates in the regulation of food intake and that activation of the serotonergic system decreases food intake in rats (Blundell, 1984; Curzon, 1990). It has been reported that the central 5-HT2A/2C receptor agonist DOI or 5-HT2C receptor agonist mCPP induces a decrease in food intake in rats and that these receptors may be mediated by the central effects of 5-HT on food intake (Aulakh et al., 1992; Schechter and Simansky, 1988; Kennet and Curzon, 1991). However, the involvement of the peripheral 5-HT2 receptor in food intake is not well established and the effects of the peripheral 5-HT2 receptor agonist is not yet clear. Therefore, in this study, we investigated the effects of the peripheral 5-HT2 receptor agonist α-methyl-5-HT on the food intake of rats.

Keywords

Cage Serotonin Tryptophan Noma Ketanserin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aulakh, C.S., Hill, J.L., Yoney, H.T., and Murphy, D.L., 1992, Evidence for involvement of 5-HT1C and 5-HT2 receptors in the food intake suppressant effects of l-(2, 5-dimethoxy 4-iodophenyl)-2-aminopropane (DOI), Psychopharmacology 109: 444.CrossRefGoogle Scholar
  2. Baker, B.C., Duggan, J.P., and Booth, D.A., 1988, Effects of DL-fenfluramine and Uxylamidine on gastric emptying of maintenance diet in freely feeding rats, Eur. J. Pharmacol 150: 137.CrossRefGoogle Scholar
  3. Blundell, J.E., 1984, Serotonin and appetite, Neuropharmacology 23: 1537.CrossRefGoogle Scholar
  4. Curzon, G., 1990, Serotonin and appetite, Ann. N.Y. Acad. Sci. 600: 521. Fozard, J.R., 1989, “The Peripheral Actions of 5-Hydroxytryptamine,” Oxford University Press, Oxford.Google Scholar
  5. Kennet, G.A., and Curzon, G., 1991, Potencies of antagonists indicate that 5-HT1 receptors mediate l-3(chlo- rophenyl)piperazine-induced hypophagia, Br. J. Pharmacol. 103: 8.Google Scholar
  6. Rowlland, N., and Carlton, J., 1986, Inhibition of gastric emptying by peripheral and central fenfluramine in rats: Correlation with anorexia, Life Sci. 34: 2495.CrossRefGoogle Scholar
  7. Schechter,L.E., and Simansky, K.J., 1988, l-<2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) exerts an anorexic action that is blocked by 5-HT2 antagonists in rats, Psychopharmacology 94: 342.Google Scholar
  8. Smith, G.P., and Epstein, A.N., 1969, Increased feeding response to decreased glucose Utilization in the rat and monkey, Am. J. Physiol. 217: 1083.Google Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • J. Yamada
    • 1
  • Y. Sugimoto
    • 1
  • T. Yoshikawa
    • 1
  • T. Noma
    • 1
  • K. Horisaka
    • 1
  1. 1.Department of PharmacologyKobe Pharmaceutical UniversityMotoyamakita-machi, Higashinada-ku, KobeJapan

Personalised recommendations