Macrophages Modulate Liver Cell Function via Tryptophan Metabolites

  • Y. Nagamura
  • K. Uesugi
  • J. Naito
  • K. Saitoh
  • A. Noma
  • I. Ishiguro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 398)

Abstract

We have reported that administration of tryptophan (Trp) usually cures hepatic injury caused by carbontetrachrolide but occasionally causes aggravation of it and the serum concentration of kynurenine (Kyn) in hepatic injured mouse increases even though the low activity of tryptophandioxygenase (TDO) in hepatic injury. We will discuss that the accel¬eration of Kyn generation would be caused by macrophage(MP) and some Trp metabolites may play an important role in both the cure of hepatic injury or aggravation of it.

Keywords

HPLC Graphite Acetone Depression Tryptophan 

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Y. Nagamura
    • 1
  • K. Uesugi
    • 1
  • J. Naito
    • 1
  • K. Saitoh
    • 2
  • A. Noma
    • 2
  • I. Ishiguro
    • 2
  1. 1.Fujita Health UniversityToyoake AichiJapan
  2. 2.Gifu UniversityTukasamachi GifuJapan

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