Abstract
We have reported that administration of tryptophan (Trp) usually cures hepatic injury caused by carbontetrachrolide but occasionally causes aggravation of it and the serum concentration of kynurenine (Kyn) in hepatic injured mouse increases even though the low activity of tryptophandioxygenase (TDO) in hepatic injury. We will discuss that the accel¬eration of Kyn generation would be caused by macrophage(MP) and some Trp metabolites may play an important role in both the cure of hepatic injury or aggravation of it.
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© 1996 Plenum Press, New York
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Nagamura, Y., Uesugi, K., Naito, J., Saitoh, K., Noma, A., Ishiguro, I. (1996). Macrophages Modulate Liver Cell Function via Tryptophan Metabolites. In: Filippini, G.A., Costa, C.V.L., Bertazzo, A. (eds) Recent Advances in Tryptophan Research. Advances in Experimental Medicine and Biology, vol 398. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0381-7_59
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DOI: https://doi.org/10.1007/978-1-4613-0381-7_59
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-8026-9
Online ISBN: 978-1-4613-0381-7
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