Advertisement

The Effects of Induced Kynurenine Pathway on Immunocytochemical Changes in Rat Tissues Following Excessive L-Tryptophan Consumption

  • N. Ronen
  • B. Gross
  • D. Ben-Shachar
  • E. Livne
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 398)

Abstract

During the past decade it has been reported that diets containing excessive L-tryptophan have caused multisystemic manifestations in humans, known as Eosinophilia Myalgia Syndrome (EMS) (Duffy, 1992). Abnormal metabolism of tryptophan was also reported in clinical syndromes such as carcinoid syndrome (Cooper et al., 1991), scleroderma-like syndrome (Varge et al., 1990; Bruce et al., 1990; Smith et al., 1990), eosinophilic fasciitis (Freis et al., 1973), idiopathic scleroderma (Stenerg et al., 1980) and systemic sclerosis (Freis et al., 1973). Inflammatory responses were elicited in all these syndromes as leukocyte infiltration and fibroblast proliferation were constantly seen in histological sections from lung skin and muscle tissues. It is thus possible that excessive L-tryptophan intake is involved in stimulation of the immune system. However, the mechanism by which tryptophan or its metabolites are involved in these processes is not yet understood. Since it is impossible to precisely follow such effects in humans, it was the purpose of the present study to follow the effects of L- tryptophan and its metabolites in an animal model that demonstrates similar effects to those observed in human tissues.

Keywords

Gastrocnemius Muscle Quinolinic Acid Carcinoid Syndrome Kynurenic Acid Kynurenine Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bruce F., Werth V.P., Rook A.H., O’Connor C.R., Schumacher H.R., 1990, L-Tryptophan ingestion associated with eosinophilic fasci but not progressive systemic sclerosis. Ann. Int. Med.112:758.Google Scholar
  2. Cooper J.R.., Bloom F.E., Roth R.H., 1991, In:Carcinoid syndrome. The Biochemical Basis of Neuropharmacology. Serotonin (5- hydroxytryptamine) and Histamine. 6th Edition. New York, Oxford. Oxford University Press, pp.338–280.Google Scholar
  3. Duffy J., 1992, The lessons of Eosinophilia-Myalgia Syndrome. Hospital Practice30:65.Google Scholar
  4. Freese B.A., Kenton J., Swartz B.A., Mattew J., 1990, Kynurenine metabolites of tryptophan:Implications for neurologic diseases. Neurology40:691.Google Scholar
  5. Freis J.F., Lingren J.A., Bull M.J., 1973, Scleroderma-like lesions and Carcinoid syndrome. Arch. Intern. Med.131:550.Google Scholar
  6. Heyes M.P., Saito K., Crowley J.S., 1992, Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurolgic disease. Brain. 115:1249.CrossRefGoogle Scholar
  7. Leonhardt A.B., Neal J.W., Kuln J.A., Schwarz M., Plimmer J.R., 1986, Quinolinic acid:An endogenous metabolite that produces axon-sparing lesions in rat brain. Science. 219:316.Google Scholar
  8. Saito K., Crowley J.S., Markry S.P., Heyes M.P., 1993, A mechanism for increased quinolinic acid formation following acute systemic immune stimulation. J. Biol Chem.268:15496.Google Scholar
  9. Smith S.A., Roelofs R.I., Gertner E., 1990, Microangiopathy in eosinophilia-myalgia syndrome. J.Rheumatol.17:1544.Google Scholar
  10. Stenerg E.M., Van Woert M.H., Young S.N., Magnussen I.B., 1980, Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. New Engl. J. Med.303:782.CrossRefGoogle Scholar
  11. Varesio L., Calyton M., Ruffman E., Radzioch D., 1990, Picolonic acid, a catabolite of tryptophan, as the second signal in the activation of interferon-γ-primed macrophages. J. Immunol.145:4265.Google Scholar
  12. Varge J., Peltonen J., Uitto J., Jimenez S., 1990, Development of diffuse fasciitis with eosinophilia during L-tryptophan treatment:Demonstration of Elevated Type I Collagen gene expression in affected tissues. Annals Int. Med.112:344.Google Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • N. Ronen
    • 1
  • B. Gross
    • 2
  • D. Ben-Shachar
    • 1
  • E. Livne
    • 1
  1. 1.Bruce Rappaport Faculty of MedicineIsrael
  2. 2.Dept. NeurologyCarmel Medical Center and Bruce Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifaIsrael

Personalised recommendations