Detection of Botulinum Neurotoxins Using Optical Fiber-Based Biosensor

  • Bal Ram Singh
  • Melissa A. Silvia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 391)


Botulinum neurotoxins, produced by the anaerobic bacterium Clostridium botulinum, are the most toxic poisons known to man. The neurotoxins are food poisons. Once ingested, the neurotoxin is absorbed through the intestinal mucosal layer into the blood stream. It acts at the neuromuscular junction to inhibit the release of acetylcholine (a neurotransmitter) from nerve endings (Simpson, 1989). The result is the dreaded botulism disease, which is manifested by flaccid muscle paralysis.


Botulinum Neurotoxin Tetanus Toxin Clostridium Botulinum Sandwich Immunoassay Biological Warfare 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Bal Ram Singh
    • 1
  • Melissa A. Silvia
    • 1
  1. 1.Department of ChemistryUniversity of Massachusetts DartmouthNorth DartmouthUSA

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