K252a and Staurosporine Microbial Alkaloid Toxins as Prototype of Neurotropic Drugs

  • Philip Lazarovici
  • David Rasouly
  • Lilach Friedman
  • Rinat Tabekman
  • Haim Ovadia
  • Yuzuru Matsuda
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 391)

Abstract

Protein kinases are enzymes that transfer a phosphate group from ATP to an acceptor amino acid in a substrate protein (Edelman et al., 1987). Protein kinases which transfer the phosphate to alcohol groups as acceptor are called serine/threonine kinases and those to a phenolyc group as acceptor are called protein tyrosine kinases. While certain tyrosine kinases are domains of growth factor receptors (Hunter, 1991), serine/threonine kinases are classified by their second messenger activators: cAMP dependent (PKA), cGMP dependent (PKG), calcium-phospholipid dependent (PKC), calcium-calmodulin dependent (CaMK), etc (Nairn et al., 1985). Protein phosphorylation of different cellular substrates by protein kinases is an important messenger switch in signal transduction for many plasma membrane receptors leading to a defined biological response (Kikkawa and Nishizuka, 1986). Therefore, in order to elucidate and manipulate receptor signal transduction pathways, potent and selective inhibitors would be of great value.

Keywords

Tyrosine Tuberculosis Bacillus Alkaloid Streptomyces 

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Philip Lazarovici
    • 1
  • David Rasouly
    • 1
  • Lilach Friedman
    • 1
  • Rinat Tabekman
    • 1
  • Haim Ovadia
    • 2
  • Yuzuru Matsuda
    • 3
  1. 1.Department of Pharmacology and Experimental Therapeutics School of Pharmacy, Faculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael
  2. 2.Department of NeurologyHadassah Medical CenterJerusalemIsrael
  3. 3.Tokyo Research LabsKyowa Hakko Kogyo Co. Ltd.Machida-Shi, TokyoJapan

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