Abstract
Development of a vaccine to protect against infection with HIV-1 or to enhance antiviral immunity after HIV-1 has established itself in the host, is a major challenge to researchers. The virus has evolved many successful ways of evading the immune system which include its innate ability to mutate immunodominant regions and to lie dormant for many years as an integrated part of the human genome. In addition, the major target of HIV-1 is the CD4+ T-helper cell (Lane and Fauci, 1985). This cell plays a central role in the induction of effector cells responses to viruses. Early on following infection CD4+ Th cells are decreased in function and gradually are also decreased in number. Since these helper cell are required for specific immune responses to protein antigens, in terms of antibody and cytotoxic T cell responses (CTL), the host loses ability to attack the virus and to ward off other infections. The vaccines that are currently in clinical trials involve the use of proteins which probably require normal function of CD4+ Th in order that primary and secondary immune responses take place.
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© 1995 Plenum Press, New York
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Golding, B., Inman, J., Golding, H. (1995). Design of Vaccines for the Induction of Antibody Responses in Th-Cell Deficient Individuals. In: Gregoriadis, G., McCormack, B., Allison, A.C. (eds) Vaccines. Nato Science Series, vol 282. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0357-2_6
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DOI: https://doi.org/10.1007/978-1-4613-0357-2_6
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