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DNA-Based Immunization: Prospects For a Hepatitis B Vaccine

  • Chapter
Vaccines

Part of the book series: Nato Science Series ((NSSA,volume 282))

Abstract

Nucleic acid-based immunization refers to the induction of an immune response to an antigen expressedin vivo subsequent to the introduction of coding sequences in the form of either DNA or RNA. To date, most examples of nucleic acid-based immunization have used DNA encoding a polypeptide sequence, thus the subsequent discussion will be restricted to DNA-based immunization (for an example of an RNA-based vaccine, see Martinon et al., 1993). Administration of DNA encoding an antigen as a vaccine potentially offers several advantages over administration of the antigen itself, as is the case with many classical vaccines used currently in humans. These advantages and their significance are discussed in the next part (Section II).

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Author information

Authors and Affiliations

  1. Loeb Medical Research Institute, Ottawa Civic Hospital, Faculties of Health Sciences and Medicine, University of Ottawa, 1053 Smyth Road, K1Y 4E9, Ottawa, Canada

    Heather L. Davis

  2. Département de Biologie Moléculaire, Inst Pasteur, 25. rue du Dr Roux, 75724, Paris cedex, France

    Heather L. Davis & Robert G. Whalen

Authors
  1. Heather L. Davis
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  2. Robert G. Whalen
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Editor information

Editors and Affiliations

  1. School of Pharmacy, University of London, London, England

    Gregory Gregoriadis  & Brenda McCormack  & 

  2. Dawa Corporation, Belmont, California, USA

    Anthony C. Allison

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© 1995 Plenum Press, New York

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Davis, H.L., Whalen, R.G. (1995). DNA-Based Immunization: Prospects For a Hepatitis B Vaccine. In: Gregoriadis, G., McCormack, B., Allison, A.C. (eds) Vaccines. Nato Science Series, vol 282. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0357-2_16

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  • DOI: https://doi.org/10.1007/978-1-4613-0357-2_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8014-6

  • Online ISBN: 978-1-4613-0357-2

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