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Adjuvants for New and Improved Vaccines

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Vaccines

Part of the book series: Nato Science Series ((NSSA,volume 282))

Abstract

This series of NATO Advanced Studies Institutes is intended to bridge the widening gap between basic immunobiology and its application to vaccination. There has been a rapid expansion of knowledge about subsets of lymphocytes and accessory cells, the chemistry of immunoglobulins, cytokines, adhesion molecules and the complex interactions required for cellular and humoral responses to antigenic stimulation. A great deal of information has accumulated about the structure of bacterial, viral and other antigens. Many of these can be produced by recombinant DNA technology or peptide synthesis. Yet the practice of vaccination has changed very little during the past decade. New live virus vaccines have been introduced, including attenuated varicella-zoster virus (Oka strain of VZV, Takahashi, 1990). However, this strain, and other live viruses, can produce severe infections in immunocompromized recipients (Gershon et al., 1984). It is now recognized that immunodeficiency is commoner than formerly believed, for nutritional and other reasons (Chandra, 1991). Hence live viruses and bacteria, including vectors of antigens, may have undesirable effects in some recipients, and emphasis is now placed on optimizing the efficiency of subunit vaccines.

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  1. Dawa Corporation, Belmont, CA, USA

    Anthony C. Allison

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  1. School of Pharmacy, University of London, London, England

    Gregory Gregoriadis  & Brenda McCormack  & 

  2. Dawa Corporation, Belmont, California, USA

    Anthony C. Allison

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© 1995 Plenum Press, New York

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Allison, A.C. (1995). Adjuvants for New and Improved Vaccines. In: Gregoriadis, G., McCormack, B., Allison, A.C. (eds) Vaccines. Nato Science Series, vol 282. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0357-2_1

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  • DOI: https://doi.org/10.1007/978-1-4613-0357-2_1

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