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Endothelial Function and Malignant Coagulopathy

  • N. W. R. Wickham
  • A. Bradshaw
  • J. Evans
  • D. H. Bevan
  • J. Mansi
Part of the NATO ASI Series book series (NSSA, volume 281)

Abstract

Patients with cancer suffer an increased incidence of thrombo-embolic events. This is particularly true of breast, lung, gastro-intestinal, gynecological and prostatic tumors (Jacobs and Yeager, 1986). This risk is further enhanced by metastatic disease and chemotherapy (Goodnough et al., 1984). Many coagulation abnormalities have been detected in these patients, but none have been shown to be predictive of subsequent thrombo-embolism (Nand etal., 1987; Bick, 1978; Nand and Messmore, 1990; Miller and Heilmann, 1988; Zurbon et al., 1990). The fact that thrombo-embolic events often occur or recur despite apparently adequate anticoagulation with warfarin is further evidence of the unsatisfactory nature of conventional assays in indicating thrombotic status in these patients.

Keywords

Porcine Aortic Endothelial Cell Adequate Anticoagulation Recombinant Tumor Necrosis Factor Thrombotic Status Subsequent Thrombosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bevilacqua, MP., Pober, J.S., Majeau, G.R., Fiers, W., Cotran, R.S. and Gimbrone, M.A.J., 1986, Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium. Proc. Natl Acad. Sci. USA 83 (12): 4533.PubMedCrossRefGoogle Scholar
  2. Bevilacqua, M.P., Pober, J.S., Majeau, G.R., Cotran, R.S., and Gimbrone, M.A.J., 1984, Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J. Exp. Med. 160 (2): 618.PubMedCrossRefGoogle Scholar
  3. Bick, R.L., 1978, Alterations of hemostasis associated with malignancy: etiology, pathophysiology, diagnosis and management. Semin. Thromb. Hemost. 5 (1): 1.PubMedGoogle Scholar
  4. Casey, M.L., Word, R.A. andMacDonald,P.C., 1991, Cytokine stimulated endothelin release from endothelial cells. LifeSci. 48 (14): 1379.Google Scholar
  5. Cernacek, P. and Stewart, D.J., 1989, Immunoreactive endothelin in human plasma: marked elevations in patients in cardiogenic shock. Biochem. Biophysic. Res. Commun. 161: 562.CrossRefGoogle Scholar
  6. Dosne, AM., Dubor, F., Lutcher, F., Parant, M. and Chedid, L., 1988, Tumor necrosis factor (TNF) stimulates plasminogen activator inhibitor (PAI) production by endothelial cells and decreases blood fibrinolytic activity in the rat Thromb. Res. Suppl. 8: 115.Google Scholar
  7. Endo, S., Inooka, R, Ishibashi, Y., Kitada, C., Mizuta, E. and Fujino, M, 1990, Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells. Biochem. Biophys. Res. Commun. 166 (1): 324.CrossRefGoogle Scholar
  8. Goodnough L.T., Saito, H., Manni, A., Jones, P.K. and Pearson, O.H., 1984, Increased incidence of thromboembolism in stage IV breat cancer patients treated with a five-drug chemotheraphy regimen. A study of 159 patients. Cancer 54 (7): 1264.PubMedCrossRefGoogle Scholar
  9. Ishibashi, M, Saito, K., Watanabe, K., Uesugi, S., Furue, H. and Yamaji, T., 1991, Plasma Endothelin-1 levels in patients with disseminated intravascular coagulation. N. Engl. J. Med. 324 (21): 1513.CrossRefGoogle Scholar
  10. Jacobs M.B. and Yeager M., 1986, Idiopathic deep vein thrombosis in an apparently healthy patient as a premonitory sign of occult cancer. Cancer 57 (9): 1846.CrossRefGoogle Scholar
  11. Kobayashi, T., Shimada, K., and Ozawa, T., 1990, Human recombinant interleukin-1 beta- and tumor necrosis factor alpha- mediated suppression of heparin-like compounds on cultured porcine aortic endothelial cells. J. Cell Physiol. 144 (3): 383.PubMedCrossRefGoogle Scholar
  12. Koller, J., Mair, P., Wieser, C., Pomnaroli, A., Puschendorf, B. and Herold, M., 1991, Endothelin and big endothelin concentrations in injured patients. N. Engl. J. Med. 325 (21): 1518.PubMedGoogle Scholar
  13. Lerman, A., Edwards, B.S., Hallett, J.W., Heublein, D.M., Sandberg, S.M. and Burnett Jr, J.C., 1991, Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N. Engl. J. Med. 325 (14): 997.PubMedCrossRefGoogle Scholar
  14. Mannucci, P.M., Cugno, M, Bottasso, B., Marongiu, F., Maniezzo, M., Vaglini, M., and Cascinelli, N., 1990, Changes in fibrinolysis in patients with localized tumors. Eur. J. Cancer 26 (2): 83.PubMedCrossRefGoogle Scholar
  15. Miller, B. and Heilmann, L., 1988, Hemorheologic variables in breast cancer patients at the time of diagnosis and during treatment. Cancer 62 (2): 350.PubMedCrossRefGoogle Scholar
  16. Nachman, R.L., Hajjar, K.A., Silverstein, R.L. and Dinarello, C.A, 1986, Interleukin induces endothelial cell synthesis of plasminogen activator inhibitor. J. Exp. Med. 163 (6): 1595.PubMedCrossRefGoogle Scholar
  17. Nand, S., Fisher, S.G., Salgia, R. and Fisher R.I., 1987, Hemostatic abnormalities in untreated cancer: incidence and correlation with thrombotic and hemorrhagic complications. J. Clin. Oncol. 5 (12): 1998.PubMedGoogle Scholar
  18. Nand, S. and Messmore, H., 1990, Hemostasis in malignancy. Am. J. Hematol. 35 (1): 45.PubMedCrossRefGoogle Scholar
  19. Ohnishi, A., Yamaguchi, K., Kusuhara, M., Abe, K. and Kimura, S., 1989, Endothelin potentiates growth factorstimulated DNA synthesis in Swiss 3T3 cells. Jpn. J. Cancer Res. 80 (4): 302.PubMedCrossRefGoogle Scholar
  20. Zurbon, K.H., Duscha, H., Gram, J., and Bruhn, H.D., 1990, Investigations of coagulation system and fibrinolysis in patients with disseminated adenocarcinomas and non-Hodgkin’s lymphomas. Oncology 47 (5): 376.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • N. W. R. Wickham
    • 2
  • A. Bradshaw
    • 3
  • J. Evans
    • 1
  • D. H. Bevan
    • 2
  • J. Mansi
    • 1
  1. 1.Clinical OncologySt George’s HospitalLondonUK
  2. 2.Department of HaematologySt George’s HospitalLondonUK
  3. 3.Department of HaematologyHammersmith HospitalLondonUK

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