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The Pulmonary Vasodilatory Properties of PGE1 are Blunted after Experimental Single Lung Transplantation

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Vascular Endothelium

Part of the book series: NATO ASI Series ((NSSA,volume 281))

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Abstract

Prostaglandin E1 (PGE1 is a short-lived powerful vasodilator, which modifies platelet and neutrophil function and exerts a cytoprotective effect. In search of improved pulmonary preservation techniques PGE1 has been extensively studied as an adjunct to the crystalloid flush solutions or in donor pretreatment. Less attention has been paid to its possible usefulness when administered during the reperfusion period. Therefore, we evaluated the effects of PGE1-infusion on pulmonary hemodynamics and gas exchange during the first four hours of reperfusion of a pig left lung allotransplantation.

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References

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Helsinki University Central Hospital, Helsinki, Finland

    Sinikka Kukkonen MD & Hannu Toivonen MD, PhD

  2. Department of Thoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland

    Lasse Heikkilä MD, Kalervo Verkkala MD & Severi Mattila MD

Authors
  1. Sinikka Kukkonen MD
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  2. Hannu Toivonen MD, PhD
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  3. Lasse Heikkilä MD
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  4. Kalervo Verkkala MD
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  5. Severi Mattila MD
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Editor information

Editors and Affiliations

  1. Medical College of Georgia, Augusta, Georgia, USA

    John D. Catravas

  2. Boston University School of Medicine, Boston, Massachusetts, USA

    Allan D. Callow

  3. T Cell Sciences, Inc., Needham, Massachusetts, USA

    Una S. Ryan

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© 1996 Plenum Press, New York

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Kukkonen, S., Toivonen, H., Heikkilä, L., Verkkala, K., Mattila, S. (1996). The Pulmonary Vasodilatory Properties of PGE1 are Blunted after Experimental Single Lung Transplantation. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 281. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0355-8_76

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  • DOI: https://doi.org/10.1007/978-1-4613-0355-8_76

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8013-9

  • Online ISBN: 978-1-4613-0355-8

  • eBook Packages: Springer Book Archive

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