Interactions of Superoxide Dismutases with Nitric Oxide

  • Brian Day
  • Tim Oury
  • James D. Crapo
Part of the NATO ASI Series book series (NSSA, volume 281)


Superoxide (O2 ) is an important component of a variety of vascular inflammatory disorders including reperfusion injuries, hemorrhagic shock, oxygen toxicities, infections, neoplasia and apoptosis. Extracellular superoxide dismutase (EC-SOD) has been found in the extracellular spaces and fluids where it is thought to defend against O2 produced by inflammatory cells. Nitric oxide (NO) is also produced during inflammatory reactions and has some anti-inflammatory properties. In the extracellular spaces the primary species that will react with NO is O2 . The product of this reaction is peroxynitrite which is a strong proinflammatory mediator. Therefore, to control inflammation, the reaction of O2 with NO must be prevented. High EC-SOD levels in the extracellular spaces may act to preserve NO and thus create strong anti-inflammatory microenvironments.


Nitric Oxide Extracellular Space Hemorrhagic Shock Density Endothelial Cell Extracellular Superoxide Dismutase 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Brian Day
    • 1
  • Tim Oury
    • 1
  • James D. Crapo
    • 1
  1. 1.Pulmonary and Critical Care MedicineDuke University Medical CenterDurhamUSA

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