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Immunopharmacology Reviews Volume 2 pp 261–287Cite as

Histamine

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Abstract

Histamine has long been recognized as a mediator of acute allergic reactions in humans and was one of the first chemical substances shown to be associated with mast cells. β-Imidazolylethylamine was first synthesized in 1907 (Shore et al., 1959) and was given the name histamine (Greek, histos) because of its ubiquitous presence in animal tissues. Analyzing the effects in animals of intravenously administered histamine, Dale and Laidlaw (1910) first demonstrated the potent bronchospastic and vasodilator activity of this mediator. Later, in the same laboratory, it was noted that many of the symptoms of antigen injection into a sensitized animal could be reproduced by histamine, leading to the conclusion that it was a humoral mediator of the acute allergic response (Best et al., 1927). Lewis’s (1927) description of the wheal-and-flare response in human skin further expanded on the vascular actions of histamine. The latter observation suggested that this mediator could be released from cellular stores within the skin on appropriate stimulation. It was not until 1953, however, that histamine present in human skin was localized to mast cells of the dermis (Riley and West, 1953).

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  1. Clinical Research, Astra USA, Inc., Westborough, Massachusetts, 01581, USA

    Ross E. Rocklin

  2. Pulmonary Medicine, Newton—Wellesley Hospital, Newton, Massachusetts, 02162, USA

    Dennis J. Beer

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  1. University of South Florida College of Medicine, Tampa, Florida, USA

    John W. Hadden  & Andor Szentivanyi  & 

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Rocklin, R.E., Beer, D.J. (1996). Histamine. In: Hadden, J.W., Szentivanyi, A. (eds) Immunopharmacology Reviews Volume 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0349-7_8

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