Abstract
The initial attempts to alter the progression of neoplastic diseases in patients with certain types of cancer through the application of maximally tolerated doses of cytotoxic agents took place 40 to 50 years ago. Since that time impressive successes have been achieved in a number of malignancies. Nevertheless, there remain frequently occurring neoplasms for which there is no curative treatment. The failures are related mainly to the fact that the agents available to date are not sufficiently selective in their antitumor action; therefore, even a relatively small degree of natural or acquired resistance cannot be overcome by dose escalation without incurring unacceptable toxicity. Although the search for new cytotoxic agents with improved antitumor selectivity is continuing, alternative therapeutic approaches are also being aggressively sought in several different directions. As an example, the increasing knowledge of the molecular mechanisms regulating the cancer cell provides new sites for which it should be possible to rationally design new agents with unique anticancer specificities. Likewise, based on information about the interactions between tumor and host, approaches that exploit both the immunological and the nonimmunological phenomena involved in these interactions are being tested. This chapter is concerned with the possibility of exploiting antitumor host defenses of the immunological type through the action of anticancer agents capable of inducting therapeutically favorable immunomodulation.
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Ehrke, M.J., Mihich, E. (1996). Immunopharmacology of Anticancer Agents. In: Hadden, J.W., Szentivanyi, A. (eds) Immunopharmacology Reviews Volume 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0349-7_4
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