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Retroviruses and Autoimmunity

  • Chapter
Microorganisms and Autoimmune Diseases

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

Autoimmunity is an immune reaction against self constituents. Autoimmune phenomena are noted in a spectrum of clinical scenarios, ranging from the normal physiological processes and consequences of aging to severe pathological conditions which may be organ-specific or general.1 Autoimmunity is likely to be involved in the etiology and/or pathogenesis of a variety of diseases such as rheumatoid arthritis, systemic lupus erythematosus, and diabetes. Under normal circumstances the immune system provides a response to insults such as neoplasm, injury, and infection. In pathological immune responses, however, the normal functioning of the immune system undergoes dysregulation resulting in an autoaggressive immune response. The etiology and pathogenesis of many autoimmune disorders remains unsolved despite a tremendous growth in understanding of how

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Author information

Authors and Affiliations

  1. Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida, 33612, USA

    Kenneth E. Ugen

  2. Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA

    Laura Fernandes

  3. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    H. Ralph Schumacher & William V. Williams

  4. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    Bin Wang & David B. Weiner

Authors
  1. Kenneth E. Ugen
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  2. Laura Fernandes
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  3. H. Ralph Schumacher
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  4. William V. Williams
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  5. Bin Wang
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  6. David B. Weiner
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Editor information

Editors and Affiliations

  1. College of Medicine, University of South Florida, Tampa, Florida, USA

    Herman Friedman

  2. School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, USA

    Noel R. Rose

  3. University of Pisa, Pisa, Italy

    Mauro Bendinelli

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© 1996 Plenum Press, New York

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Ugen, K.E., Fernandes, L., Schumacher, H.R., Williams, W.V., Wang, B., Weiner, D.B. (1996). Retroviruses and Autoimmunity. In: Friedman, H., Rose, N.R., Bendinelli, M. (eds) Microorganisms and Autoimmune Diseases. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0347-3_10

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  • DOI: https://doi.org/10.1007/978-1-4613-0347-3_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45236-9

  • Online ISBN: 978-1-4613-0347-3

  • eBook Packages: Springer Book Archive

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