Abstract
Of all the microorganisms, bacteria, especially, seem to exert continuous pressure on the immune system. The epithelial surfaces of the skin and the intestinal tract are colonized by a wide variety of bacterial species, forcing the immune system into a situation where it has to scan continuously an immense repertoire of foreign antigenic determinants. It may be self-evident that as much as the healthy immune system does not develop an aggressive response directed against self antigens, or autoantigens, the same immune system is not tuned to mount continuous and aggressive responses to antigens present in the resident bacterial flora. Nonetheless, the capacity to respond must be there. Within every healthy immune system, cells specific for autoantigens are present, and their potential for causing disease has been demonstrated in a variety of experimental autoimmune disease models. The mechanisms by which the immune
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REFERENCES
Cohen, I. R., 1986, Regulation of autoimmune disease: Physiological and therapeutic, Immunol.
Toivanen, A., and Toivanen, P., 1991, Reactive vs. rheumatoid arthritis: What is to be learned?, in: Trends in Rheumatoid Arthritis Research( P. Hedquist,J. R. Kalden, R. Miiller-Peddinghaus and D. R. Robinson, eds.), Eular Publishers, Basel, Switzerland, pp. 29–35.
Whitehouse, D. J., Whitehouse, M. W., and Pearson, C. M., 1969, Passive transfer of adjuvant induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes, Nature 224: 1322 - 1324.
Holoshitz, J., Naparstek, Y, Ben-Nun, A., and Cohen, I. R., 1983, Lines of T lymphocytes induce or vaccinate against autoimmune arthritis, S dence 219: 56 - 58.
Klasen, I. S., KoolJ., Melief, M. J., and Hazenberg, M., 1992, Arthritis autoreactive T cell lines obtained from rats after injection of intestinal bacterial cell wall fragments, Cell Immunol. 139: 455 - 467.
Cohen, I. R., 1992, The cognitive paradigm and the immunological homunculus, I mmunol . Today 13: 490 - 494.
Hammerling, G.J., Schonrich, G., Ferber, I., and Arnold, B., 1993, Peripheral tolerance as a multi-step mechanism, Immunol. Rev. 133: 93 - 103.
Kohashi, O., Kohashi, Y, Ozawa, A., and Shigematsu, N., 1986, Suppressive effect of E. colion adjuvant-induced arthritis in germ-free rats, Arthritis Rheum. 29: 547 - 552.
Thompson, S. J., and Elson, C. J., 1993, Susceptibility to pristane-induced arthritis is altered with changes in bowel flora, Immunol. Lett. 36: 227 - 230.
Bowman, M. A., Leiter, E. H., and Atkinson, M. A., 1994, Prevention of diabetes in the NOD mouse: Implications for therapeutic intervention in human disease, Immunol. Today 15: 115 - 120.
Sadelain, M. W. J., Qin, H. Y, Sumoski, W., Parfrey, N., Singh, B., and Rabinovitch, A., 1990, Prevention of diabetes in the BB rat by early immunotherapy using Freund’s adjuvant,J. Autoimmun. 3: 671–680.
Shehadh, N., Calcinaro, F., Bradley, B.J., Brucklim, I., Vardi, P., and Lafferty, KJ., 1994, Effect of adjuvant therapy on development of diabetes in mouse and man, Lancet 343: 706–707.
Van Eden, W., Thole, J. E. R., van der Zee, R., Noordzij, A., van Embden, J. D. A., Hensen, E. J., and Cohen, I. R., 1988, Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis, Nature 331: 171–173.
Van Eden, W., Hogervorst, E. J., Hensen, E.J., van der Zee, R., van Embden,J. D. A., and Cohen, I. R., 1989, A cartilage-mimicking T cell epitope on a 65K mycobacterial heat shock protein: Adjuvant arthritis as a model for human rheumatoid arthritis, Curr. Top. Microbiol. Immunol. 145: 27–43.
Van Eden, W., 1991, Heat-shock proteins and the immune system, Immunol. Rev. 121: 5–28.
Welch, W. J., 1993, How cells respond to stress, Sä. Am. 268: 56–62.
Boog, C.J. P., de Graeff-Meeder, E. R., Lucassen, M. A., van der Zee, R., Voorhorst-Ogink, M. M., van Kooten, P.J. S., Geuze, H.J., and van Eden, W., 1992, Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis, J. Exp. Med. 175: 1805–1810.
Anderton, S. M., van der Zee, R., Noordzij, A., and van Eden, W., 1994, Differential mycobacterial 65-kDa hsp T cell epitope recognition after AA inducing or protective immunization protocols,J. Immunol. 152: 3656.
Anderton, S. M., and W. van Eden, 1996, T lymphocyte recognition of hsp60 in experimental arthritis, in: Stress Proteins in Mediane (W. can Eden and D. Young, eds.), Marcel Dekker, New York, pp. 73–92.
Res, R C. M., Telgt, D., Laar, J. M., Oudkerk Pool, M., Breedveld, E C, and de Vries, R. R. P., 1990, Increased antigen reactivity of mononuclear cells from sites of chronic inflammation, Lancet 336: 1406–1408.
Wilbrink, B., Holewijn, M., Bijlsma, J. W. J., van Roy, J. L. A. M., den Otter, W., and van Eden, W., 1993, Suppression of human cartilage proteoglycan synthesis by rheumatoid synovial fluid mononuclear cells activated with mycobacterial 60 kD heat-shock protein, Arthritis Rheum. 36: 514 - 518.
de Graeff-Meeder, E. R., van der Zee, R., Rijkers, G. X, Schuurman, H. J., Kuis, W., Bijlsma, J. W. J., Zegers, B.J. M., and van Eden, W., 1991, Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis, Lancet 337: 1368 - 1372.
. deGraeff-Meeder, E. R., van Eden, W., Rijkers, G. T., Kuis, W., Voorhorst-Ogink, M. M., van der Zee, R., Schuurman, H.-J., Helders, P. J. M., and Zegers, B. J. M., Juvenile chronic arthritis: T-cell reactivity to human hsp60 in patients with a favorable course of arthritis, J. Clin. Invest. 95:934-940.
Rosenthal, M., Bahous, L, and Ambrosini, G., 1991, Long term treatment of rheumatoid arthritis with OM-8980. A retrospective study, J. Rheum. 18: 1790 - 1793.
Vischer, T. L., 1988, A double blind multi center study of OM-8980 and auranofin in rheumatoid arthritis, Ann. Rheum. Dis. 47: 582 - 587.
Evavold, B. D., Sloan-Lancaster, J., and Allen, P. H., 1993, Tickling the TcR selective T-cell functions stimulated by altered peptide ligands, Immunol. Today 14: 602 - 609.
Van Eden, W., Wauben, M. H. M., Boog, C.J. P., and van der Zee, R., 1993, Inhibition of autoimmune T cells by “competitor modulator” peptides, in: Progress in Immunology( J. Gergely, ed.), Springer Verlag, Budapest, pp. 587 - 594.
Wauben, M. H. M., Boog, C.J. P., van der Zee, R.,Joosten, L, Schlief, A., and van Eden, W., 1992, Disease inhibition by MHC binding peptide analogues of disease associated epitopes: More than blocking alone, J. Exp. Med. 176: 667 - 677.
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© 1996 Plenum Press, New York
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Eden, W.V., Anderton, S.M., Prakken, A.B.J., Van Der Zee, R. (1996). Bacterial Heat-Shock Proteins and Autoimmune Disease. In: Friedman, H., Rose, N.R., Bendinelli, M. (eds) Microorganisms and Autoimmune Diseases. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0347-3_1
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DOI: https://doi.org/10.1007/978-1-4613-0347-3_1
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