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Bacterial Heat-Shock Proteins and Autoimmune Disease

  • W. Van Eden
  • S. M. Anderton
  • A. B. J. Prakken
  • R. Van Der Zee
Part of the Infectious Agents and Pathogenesis book series (IAPA)

Abstract

Of all the microorganisms, bacteria, especially, seem to exert continuous pressure on the immune system. The epithelial surfaces of the skin and the intestinal tract are colonized by a wide variety of bacterial species, forcing the immune system into a situation where it has to scan continuously an immense repertoire of foreign antigenic determinants. It may be self-evident that as much as the healthy immune system does not develop an aggressive response directed against self antigens, or autoantigens, the same immune system is not tuned to mount continuous and aggressive responses to antigens present in the resident bacterial flora. Nonetheless, the capacity to respond must be there. Within every healthy immune system, cells specific for autoantigens are present, and their potential for causing disease has been demonstrated in a variety of experimental autoimmune disease models. The mechanisms by which the immune

Keywords

Peripheral Tolerance Bacterial Antigen Juvenile Chronic Arthritis Autoimmune Arthritis Human Hsp60 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • W. Van Eden
    • 1
  • S. M. Anderton
    • 1
  • A. B. J. Prakken
    • 1
  • R. Van Der Zee
    • 1
  1. 1.Department of Immunology, Institute of Infectious Diseases and Immunology, Faculty of Veterinary MedicineUniversity of UtrechtUtrechtThe Netherlands

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