Abstract
Many proteins are anchored to the cell surface by hydrophobic interactions with the membrane bilayer. Several structural motifs are utilized for membrane anchorage in mammalian cells, including the covalent attachment of proteins to lipids (Saltiel et al., 1991). One such mechanism involves the linkage of proteins to a glycosylated form of phosphatidylinositol (PI), termed glycosylphosphatidylinositol (GPI). This mechanism has been detected in a variety of cell types and is utilized by over 100 membrane proteins (Ferguson and Williams, 1988; Low and Saltiel, 1988). Additionally, a glycophospholipid with several structural similarities to the GPI anchor has been described in a number of cell types (Saltiel and Cuatrecasas, 1986, 1988; Saltiel et al., 1986). This lipid, which shares the core structure of the membrane anchor and may represent a biosynthetic intermediate, undergoes a phospholipase C (PLC)-catalyzed hydrolysis in response to insulin and functionally related growth factors, generating an aqueous glycan in cells that mediates some of the actions of the hormone (Saltiel and Cuatrecasas, 1986; Saltiel et al., 1986). Although the precise relationship between the protein anchored and the hormone-sensitive free form of the lipid remains unknown, numerous similarities suggest that these glycolipids may participate in related functions in cellular regulation. This chapter focuses on the unusual properties and important roles of this unique class of lipids in cellular regulation.
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References
Alemany, S., Mato, J. M., and Stralfors, P., 1987, Phosphodephospho-control by insulin is mimicked by a phosphooligosaccharide in adipocytes, Nature 330:77–79.
Alvarez, J. F., Cabello, M. A., Feliu, J. E., and Mato, J. M., 1987, A phosphooligosaccharide mimics insulin action on glycogen Phosphorylase and pyruvate kinase activities in isolated rat hepatocytes, Biochem. Biophys. Res. Commun. 147:765–771.
Alvarez, J. F., Varela, I., Ruiz-Albusac, J. M., and Mato, J. M., 1988, Localisation of the insulin-sensitive phosphatidylinositol glycan at the outer surface of the cell membrane, Biochem. Biophys. Res. Commun. 152:1455–1462.
Alvarez, L., Avila, M. A., Mato, J. M., Castano, J. G., and Varela-Nieto, I., 1991, Insulin-like effects of inositol phosphate-glycan on messenger RNA expression in rat hepatocytes, Mol. Endocrinol. 5:1062–1068.
Anderson, R.G.W., 1993, Caveolae: Where incoming and outgoing messengers meet, Proc. Natl. Acad. Sci. U.S.A. 90:10909–10913.
Bailey, C. A., Gerber, L., Howard, A. D., and Udenfriend, S., 1989, Processing at the carboxyl terminus of nascent placental alkaline phosphatase in a cell-free system: Evidence for specific cleavage of a signal peptide, Proc. Natl. Acad. Sci. U.S.A. 86:22–26.
Bangs, J. D., Hereld, D., Krakow, J. L., Hart, G. W., and Englund, P. T., 1985, Rapid processing of the carboxyl terminus of a trypanosome variant surface glycoprotein, Proc. Natl. Acad. Sci. U.S.A. 82:3207–3211.
Berger, J., Howard, A. D., Brink, L., Gerber, L., Hauber, J., Cullen, B. R., and Udenfriend, S., 1988, COOH-terminal requirements for the correct processing of a phosphatidylinositol-glycan anchored membrane protein, J. Biol. Chem. 263:10016–10021.
Berger, J., Micanovic, R., Greenspan, R. J., and Udenfriend, S., 1989, Conversion of placental alkaline phosphatase from a phosphatidylinositol-glycan-anchored protein to an integral transmembrane protein, Proc. Natl. Acad. Sci. U.S.A. 86:1457–1460.
Boothroyd, J. C., Cross, G.A.M., Hoeijmakers, J.H.J., and Borst, P., 1980, Variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic “tail” absent from purified glycoprotein, Nature 288:624–626.
Brown, D. A., and Rosy, J. K., 1992, Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface, Cell 68:533–544.
Bulow, R., Griffiths, G., Webster, P., Stierhof, Y. D., Opperdoes, F. R., and Overath, P., 1989, Intracellular localization of the GPI-specific phospholipase C of Trypanosoma brucei, J. Cell Sci. 93:233–240.
Caras, I. W., and Weddell, G. N., 1989, Signal peptide for protein secretion directing gly-cophospholipid membrane anchor attachment, Science 243:1196–1198.
Caras, I. W., Davitz, M. A., Rhee, L., Weddell, G., Martin, D. W., and Nussenzweig, V., 1987a, Cloning of decay-accelerating suggests novel use of splicing to generate two proteins, Nature 325:545–548.
Caras, I. W., Weddell, G. N., Davitz, M. A., Nussenzweig, V., and Martin, D. W., 1987b, Signal for attachment of a phospholipid membrane anchor in decay accelerating factor, Science 238:1280–1283.
Chan, B. L., Lisanti, M. P., Rodriguez-Boulan, E., and Saltiel, A. R., 1988, Insulin-stimulated release of lipoprotein lipase by metabolism of its phosphatidylinositol anchor, Science 241:1670–1672.
Chan, B. L., Chao, M. V., and Saltiel, A. R., 1989, Nerve growth factor stimulates the hydrolysis of glycosyl-phosphatidylinositol in PC-12 cells: A mechanism of protein kinase C regulation, Proc. Natl. Acad. Sci. U.S.A. 86:1756–1760.
Conzelmann, A., Spiazzi, A., and Bron, C., 1987, Glycolipid anchors are attached to Thy-1 glycoprotein rapidly after translocation, Biochem. J. 246:605–610.
Crise, B., Ruusala, A., Zagouras, P., Shaw, A., and Rose, J. K., 1989, Oligomerization of glycolipid-anchored and soluble forms of the vesicular somatitis virus glycoprotein, J. Virol. 63:5328–5333.
Davitz, M. A., Hereld, D., Shak, S., Krakow, J., Englund, P. T., and Nussenzweig, V., 1987, A glycan-phosphatidylinositol-specific phospholipse D in human serum, Science 238:81–84.
Davitz, M. A., Hom, J., and Schenkman, S., 1989, Purification of a glycosyl-PI-specific phospho-lipase D from human plasma, J. Biol. Chem. 264:13760–13764.
Deterrontegui, G., and Berthet, J., 1966, The action of insulin on the incorporation of [32P]phosphate in the phospholipids of rat adipose tissue, Biochim. Biophys. Acta 116:477–481.
Doering, T. L., Masterson, W. J., Hert, G. W., and Englund, P. T., 1990, Biosynthesis of glycosyl phosphatidylinositol membrane anchors, J. Biol. Chem. 265:611–614.
Dragsten, P., Henkart, P., Blumenthal, R., Weinstein, J., and Schlessinger, J., 1979, Lateral diffusion of surface immunoglobulin, Thy-1 antigen, and a lipid probe in lymphocyte plasma membranes, Proc. Natl. Acad. Sci. U.S.A. 76:5163–5167.
Dustin, M. L., Selveraj, P., Mattaliano, R. J., and Springer, T. A., 1987, Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface, Nature 329:846–848.
Eardley, D. D., and Koshland, M. E., 1991, Glycosylphosphatidylinositol: A candidate system for interleukin-2 signal transduction, Science 251:78–81.
Farese, R. V., Davis, J. T., Barnes, D. E., Standaert, M. L., Bebishkin, J., Hock, R., Rosie, N. K., and Pollet, R. J., 1985, The de novo phospholipid effect of insulin is associated with increases in diacylglycerol, but not inositol phosphates or cytosolic Ca, Biochem. J. 231:269–278.
Farese, R. V., Cooper, D. R., Konda, T. S., Nair, G., Standart, M. L., Davis, J. S., and Pollet, R. J., 1988a, Mechanisms whereby insulin increases diacylglycerol in BC3H1 myocytes, Biochem. J. 256:175–184.
Farese, R. V., Cooper, D. R., Konda, T. S., Nair, G., Standart, M. L., and Pollet, R. J., 1988b. Insulin provokes coordinated increases in the synthesis of phosphatidylinositol, phospha-tidylinositolphosphates and the phosphatidylinositol-glycan in BC3H1 myocytes, Biochem. J. 256:185–188.
Farese, R. V., Standaert, M. L., Yamada, K., Huang, L. C., Zhang, C., Cooper, D. R., Wang, Z., Yang, Y., Suzuki, S., Toyota, T., and Larner, J., 1994, Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin resistant, type II diabetic Goto-Kakizaki rats, Proc. Natl. Acad. Sci. U.S.A. 91:11040–11044.
Ferguson, M.A.J., and Williams, A. F., 1988, Cell-surface anchoring of proteins via glycosylphosphatidylinositol structures, Annul Rev. Biochem. 57:285–320.
Ferguson, M.A.J., Duszenko, M., Lamont, G. S., Overath, P., and Cross, G.A.M., 1986, Biosynthesis of Trypanosoma brucei variant surface glycoproteins, J. Biol. Chem. 261:356–362.
Ferguson, M.A.J., Homans, S. W., Dwek, R. A., and Rademacher, T. W., 1988, Glycosylphosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane, Science 239:753–759.
Fox, J. A., Duszenko, M., Ferguson, M.A.J., Low, M. G., and Cross, G.A.M., 1986, Purification and characterization of a novel glycan-PI specific phospholipase C from T brucei, J. Biol. Chem. 261:15767–15771.
Fox, J. A., Soliz, N. M., and Saltiel, A. R., 1987, Purification of a phosphatidylinositol-glycan specific phospholipase C from liver plasma membranes: A possible target of insulin action, Proc. Natl. Acad. Sci. U.S.A. 84:2663–2667.
Gaulton, G. N., 1991, Differential regulation of glycosylated phosphatidylinositol subtypes by insulin, Diabetes 40:1297–1304.
Gaulton, G. N., Kelly, K. L., Pawlowski, J., Mato, J. M., and Jarett, L., 1988, Regulation and function of an insulin-sensitive glycosylphosphatidylinositol during T lymphocyte activation, Cell 538:963–970.
Gottschalk, W. K., and Jarett, L., 1988, The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays, Arch. Biochem. Biophys. 261:175–185.
Gower, H. J., Barton, C. H., Elsom, V. L., Thompson, J., Moore, S. E., Dickson, G., and Walsh, F. S., 1988, Alternative splicing generates a secreted form of N-CAM in muscle and brain, Cell 55:955–964.
Hayashi, Y., Urade, R., Utsumi, S., and Kito, M., 1989, Anchoring of peptide elongation factor EF-la by phosphatidylinositol at the endoplasmic reticulum membrane, Biochem. J. 106:560–563.
He, H. T., Finne, J., and Goridis, C., 1987, Biosynthesis, membrane association, and release of N-CAM-120, a phosphatidylinositol-linked form of the neural cell adhesion molecule, J. Cell Biol. 105:2489–2500.
Hemperly, J. J., Edelman, G. N., and Cunningham, B. A., 1986, cDNA clones of N-CAM lacking a membrane-spanning region consistent with evidence for membrane attachment via a phosphatidylinositol intermediate, Proc. Natl. Acad. Sci. U.S.A. 83:9822–9826.
Hereld, D., Hart, G. W., and Englund, P. T., 1988, cDNA encoding the glycosyl-PI-specific phospholipase C of T. brucei, Proc. Natl. Acad. Sci. U.S.A. 85:8914–8918.
Hibbs, M. L., Selvaraj, P., Carpen, O., Springer, T. A., Kuster, H., Jouvin, M. H. E., and Kinet, J. P., 1989, Mechanisms for regulating expression of membrane isoforms of Fc gamma R III (CD 16), Science 246:1608–1611.
Homans, S. W., Ferguson, M.A.J., Dwek, R. A., Rademacher, T. W., Anand, R., and Williams, A. F., 1988, Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein, Nature 333:269–272.
Huang, L. C., Fonteles, M. C., Houston, D. B., Zhang, C., and Larner, J., 1993, Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo, Endocrinology 132:652–657.
Huizinga, T.W.J., van der Schoot, C. E., Jost, C., Klaassen, R., Kleijer, M., von dem Borne, A.E.G.K., Roos, D., and Tetteroo, P.A.T., 1988, The PI-linked receptor FcRIII is released on stimulation of neutrophils, Nature 333:667–669.
Ishihara, A., Hou, Y., and Jacobson, K., 1987a, The Thy-1 antigen exhibits rapid lateral diffusion in the plasma membrane of rodent lymphoid cells and fibroblasts, Proc. Natl. Acad. Sci. U.S.A. 84:1290–1293.
Ishihara, M., Fedearko, N. S., and Conrad, H. E., 1987b, Involvement of phosphatidylinositol and insulin in the coordinate regulation of proteoheparin sulfate metabolism and hepatocyte growth, J. Biol. Chem. 262:4708–4716.
Karnieli, E., Armoni, M., Cohen, P., Kanter, Y., and Rafaeloff, R., 1987, Reversal of insulin resistance in diabetic rat adipocytes by insulin therapy: Restoration of pool of glucose transporters and enhancement of glucose transport activity, Diabetes 36:925–931.
Kelly, K. L., Mato, J. M., and Jarett, L., 1986, The polar head group of a novel insulin-sensitive glycophospholipid mimics insulin action on phospholipid methyltransferase, FEBS Lett. 209:238–242.
Kelly, K. L., Mato, J. M., Merida, I., and Jarett, L., 1987a, Glucose transport and antilipolysis are differentially regulated by the polar head group of an insulin-sensitive glycophospholipid, Proc. Natl. Acad. Sci. U.S.A. 84:6404–6407.
Kelly, K. L., Merida, I., Wong, E.H.A., DiCenzo, D., and Mato, J. M., 1987b, A phos-pho-oligosaccharide mimics the effect of insulin to inhibit isoproterenol-dependent phosphorylation of phospholipid methyltransferase in isolated adipocytes, J. Biol. Chem. 262:15285–15290.
Kiechle, F. L., Jarett, L., Kotagal, N., and Popp, D. A., 1980, Isolation from rat adipocytes of a chemical mediator for insulin activation of pyruvate dehydrogenase, Diabetes 29:852–855.
Klip, A., Ramlal, T., Douen, A. G., Burdett, E., Young, D., Cartee, G. D., and Holloszy, J. O., 1988, Insulin-induced decrease in 5′-nucleotidase activity in skeletal muscle membranes, FEBS Lett. 238:419–423.
Kojima, I., Kitaoka, M., and Ogata, E., 1990, Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells, J. Biol. Chem. 265:16846–16850.
Kurosaki, T., and Ravetch, J., 1989, A single amino acid in the glycosyl phosphatidylinositol attachment domain determines the membrane topology of Fc gamma R III, Nature 342:805–807.
Lanier, L. L., Cwirla, S., Yu, G., Testi, R., and Phillips, J. H., 1989, Membrane anchoring of a human IgG Fc receptor (CD 16) determined by a single amino acid, Science 246:1611–1613.
Larner, J., Galasko, G., Cheng, K., DePaoli-Roach, A. A., Huang, L., Daggy, P., and Kellog, J., 1979, Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation, Science 206:1408–1410.
Larner, J., Huang, L. C., Schwartz, C.F.W., Oswald, A. S., Shen, T.-Y., Kinter, M., Tang, G., and Zeller, K., 1988, Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galactosamine and D-chiro-inositol, Biochem. Biophys. Res. Commun. 151:1416–1426.
Lazar, D. F., Knez, J. J., Medof, M. E., Cuatrecasas, P., and Saltiel, A. R., 1994, Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of gly-cosylphosphatidylinositol, Proc. Natl. Acad. Sci. U.S.A. 91:9665–9669.
Le Bel, D., and Beattie, M., 1988, The major protein of pancreatic zymogen granule membranes (GP-2) is anchored via covalent bonds to phosphatidylinositol, Biochem. Biophys. Res. Commun. 154:818–823.
Lisanti, M. P., Sargiacomo, M., Graeve, L., Saltiel, A. R., and Rodriguez-Boulan, E., 1988, Polarized apical distribution of glycosylphosphatidylinositol anchored proteins in a renal epithelial cell line, Proc. Natl. Acad. Sci. U.S.A. 85:9557–9561.
Lisanti, M. P., Caras, I. W., Davitz, M. A., and Rodriguez-Boulan, E., 1989a, A glycophospholipid membrane anchor acts as an apical targeting signal in polarized epithelial cells, J. Cell Biol. 109:2145–2156.
Lisanti, M. P., Darnell, J. C., Chan, B. L., Rodriguez-Boulan, E., and Saltiel, A. R., 1989b, The distribution of glycosyl-phosphoinositol anchored proteins is differentially regulated by serum and insulin, Biochem. Biophys. Res. Commun. 164:824–832.
Lisanti, M. P., Le Bivic, A., Saltiel, A. R., and Rodriguez-Boulan, E., 1990, Preferred apical distribution of glycosyl-phosphatidylinositol (GPI) anchored proteins: A highly conserved feature of the polarized epithelial cell phenotype, J. Membr. Biol. 113:155–167.
Low, M. G., and Prasad, A.R.S., 1988, A phospholipase D for the PI-anchor of cell-surface proteins is abundant in plasma, Proc. Natl. Acad. Sci. U.S.A. 85:980–984.
Low, M. G., and Saltiel, A. R., 1988, Structural and functional roles of glycosylphosphatidylinositol in membranes, Science 239:268–275.
Machicao, F., Mushack, J., Seffer, E., Ermel, B., and Haring, H. U., 1990, Mannose, glucosamine and inositol monophosphate inhibit the effects of insulin on lipogenesis. Further evidence for a role for inositol phosphate-oligosaccharides in insulin action, Biochem. J. 266:909–916.
Manchester, K. L., 1963, Stimulation by insulin of incorporation of [32P]phosphate and [14C]acetate into lipid and protein of isolated rat diaphragm, Biochim. Biophys. Acta 70:208–210.
Martiny, L., Antonicelli, F., Thuilliez, B., Lambert, B., Jacquemin, C., and Haye, B., 1990, Control by thyrotropin of the production by thyroid cells of an inositol phosphate-glycan, Cell Signalling 2:21–27.
Mato, J. M., Kelly, K. L., Abler, A., and Jarett, L., 1987a, Identification of a novel insulin-sensitive glycophospholipid from H35 hepatoma cells, J. Biol. Chem. 262:2131–2137.
Mato, J. M., Kelly, K. L., Abler, A., Jarett, L., Corkey, B. E., Cashel, J. A., and Zopf, D., 1987b, Partial structure of an insulin-sensitive glycophospholipid, Biochem. Biophys. Res. Commun. 146:764–770.
Merida, I., Pratt, J. C., and Gaulton, G. N., 1990, Regulation of interleukin 2-dependent growth responses by glycosylphosphatidylinositol molecules, Proc. Natl. Acad. Sci. U.S.A. 87:9421–9425.
Misek, D. E., and Saltiel, A. R., 1992, An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl-phosphatidylinositol mimics some of the metabolic actions of insulin, J. Biol. Chem. 267:16266–16273.
Misek, D. E., and Saltiel, A. R., 1994, An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl phosphatidylinositol promotes protein dephosphorylation in rat epididymal adipocytes, Endocrinology 135:1869–1876.
Noda, M., Yoon, K., Rodan, G. A., and Koppel, D. E., 1987, High lateral mobility of endogenous and transfected alkaline phosphatase: A phosphatidylinositol-anchored membrane protein, J. Cell Biol. 105:1671–1677.
Ortmeyer, H. K., Bodkin, N. L., Lilley, K., Larner, J., and Hansen, B.C., 1993a, Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneously diabetic rhesus monkeys, Endocrinology 132:640–645.
Ortmeyer, H. K., Huang, L. C., Zhang, L., Hansen, B. C., and Larner, J., 1993b, Chiroinositol deficiency and insulin resistance. II. Acute effects of d-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistance rhesus monkeys, Endocrinology 132:646–651.
Parker, J. C., Kiechle, F. L., and Jarett, L., 1982, Partial purification from hepatoma cells of an intracellular substance which mediates the effects of insulin on pyruvate dehydrogenase and low K m cAMP phosphodiesterase, Arch. Biochem. Biophys. 215:339–344.
Pennington, S. R., and Martin, B. R., 1985, Insulin-stimulated phosphoinositide metabolism in isolated fat cells, J. Biol. Chem. 260:11039–11045.
Phelps, B. M., Primakoff, P., Koppel, D. E., Low, M. G., and Myles, D. G., 1988, Restricted lateral diffusion of PH-20, a PI-anchored sperm membrane protein, Science 240:1780–1782.
Plourde, R., d’Alarcao, M., and Saltiel, A. R., 1992, Synthesis and characterization of insulin-mimetic disaccaride, J. Organ. Chem. 57:2606–2610.
Represa, J., Avila, M. A., Miner, C., Giraldez, F., Romero, G., Clemente, R., Mato, J. M., and Varela-Nieto, I., 1991, Glycosylphosphatidylinositol/inositol phosphoglycan: A signaling system for the low-affinity nerve growth factor receptor, Proc. Natl. Acad. Sci. U.S.A. 88:8016–8019.
Roberts, W. L., Myher, T. J., Kuksis, A., Low, M. G., and Rosenberry, T. L., 1988a, Lipid analysis of the glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase. Palmioylation of inositol results in resistance to phosphatidyl-specific phospholipase C., J. Biol. Chem. 263:18766–18775.
Roberts, W. L., Santikarn,, S., Reinhold, V. N., and Rosenberry, T. L., 1988b, Structural characterization of the glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase by fast atom bombardment mass spectrometry, J. Biol. Chem. 263:18776–18784.
Rodgers, W., Crise, B., and Rose, J. K., 1994, Signals determining protein tyrosine kinase and GPI-anchored protein targeting to a glycolipid-enriched membrane fraction, Mol. Cell. Biol. 14:-5384–5391.
Romero, G., Luttrell, L., Rogol, A., Zeller, K., Hewlett, E., and Larner, J., 1988, Phosphati-dylinositol-glycan anchors of membrane proteins: Potential precursors of insulin mediators, Science 240:509–511.
Romero, G., Gamez, G., Huang, L. C., Lilley, K., and Luttrell, L., 1990, Antiinositol glycan antibodies selectively block some of the actions of insulin in intact BC3H1 cells, Proc. Natl. Acad. Sci. U.S.A. 87:1476–1480.
Saltiel, A. R., 1987, Insulin generates an enzyme modulator from hepatic plasma membranes: Regulation of adenosine 3′,5′-monophosphate phosphodiesterase pyruvate dehydrogenase, and adenylate cyclase, Endocrinology 120:967–972.
Saltiel, A. R., and Cuatrecasas, P., 1986, Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid, Proc. Natl. Acad. Sci. U.S.A. 83:5793–5797.
Saltiel, A. R., and Cuatrecasas, P., 1988, In search of a second messenger for insulin, Am. J. Physiol. 255:C1–C11.
Saltiel, A. R., and Sorbara-Cazan, L. R., 1987, Inositol glycan mimics the action of insulin on glucose utilization in rat adipocytes, Biochem. Biophys. Res. Commun. 149:1084–1092.
Saltiel, A. R., and Steigerwalt, R. W., 1986, Purification of a putative insulin-sensitive cAMP phosphodiesterase or its catalytic domain from rat adipocytes, Diabetes 35:698–704.
Saltiel, A. R., Jacobs, S., Siegel, M., and Cuatrecasas, P., 1981, Insulin stimulates the release from liver plasma membranes of a chemical modulator of pyruvate dehydrogenase, Biochem. Biophys. Res. Commun. 102:1041–1047.
Saltiel, A. R., Siegel, M. I., Jacobs, S., and Cuatrecasas, P., 1982, Putative mediators of insulin action: Regulation of pyruvate dehydrogenase and adenylate cyclase activities, Proc. Natl. Acad. Sci. U.S.A. 79:3513–3517.
Saltiel, A. R., Doble, A., Jacobs, S., and Cuatrecasas, P., 1983, Putative mediators of insulin regulate hepatic acetyl CoA carboxylase activity, Biochem. Biophys. Res. Commun. 110:789–795.
Saltiel, A. R., Fox, J. A., Sherline, P., and Cuatrecasas, P., 1986, Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase, Science 233:967–972.
Saltiel, A. R., Sherline, P., and Fox, J. A., 1987, Insulin-stimulated diacylglycerol production results from the hydrolysis of a novel phosphatidylinositol glycan, J. Biol. Chem. 262:1116–1121.
Saltiel, A. R., Ravetch, J., and Aderem, A. A., 1991, Functional consequences of lipid-mediated protein-membrane interactions, Biochem. Pharmacol. 42:1–11.
Seals, J. R., and Czech, M. P., 1980, Evidence that insulin activates an intrinsic plasma membrane protease in generating a secondary chemical mediator, J. Biol. Chem. 255:6529–6531.
Selveraj, P., Roose, W. F., Siber, R., and Springer, T., 1988, The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal hemoglobinuria, Nature 333:565–568.
Simmons, D., and Seed, B., 1988, The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein, Nature 333:568–570.
Skillen, A. W., Hawthorne, G. C., and Turner, G. A., 1987, Serum alkaline phosphatase in rats with streptozotocin-induced diabetes, Horm. Metab. Res. 19:505–506.
Stafford, H. A., Tykocinski, M. L., Wolin, D. M., Holeus, V. M., Roose, W. F., Atkinson, J. P., and Medof, E., 1988, Normal polymorphic variations and transcription of the decay accelerating factor gene in paroxysmal noctural hemoglobinuria cells, Proc. Natl. Acad. Sci. U.S.A. 85:880–884.
Stein, J. M., and Hale, C. N., 1974, The effect of insulin on 32P incorporation into rat-fat cell phospholipids, Biochim. Biophys. Acta 337:41–49.
Steven, V. L., and Raetz, C.K.H., 1991, Detection GPI biosynthesis in extracts of three Thy-1 negative lymphoma cell mutants, J. Biol. Chem. 266:10039–10042.
Stroynowski, I., Soloski, M., Low, M. G., and Hood, L., 1987, A single gene encodes soluble and membrane-bound forms of the major histocompatibility Qa-2 antigen: Anchoring of the product by a phospholipid tail, Cell 50:759–768.
Suzuki, S., Toyoto, T., Suzuki, H., and Goto, Y., 1984, A putative second messenger of insulin action regulates hepatic microsomal glucose-6-phosphatase, Biochem. Biophys. Res. Commun. 118:40–46.
Tartakoff, A. M., and Singh, N., 1992, How to make a glycoinositol phospholipid anchor, Trends Biochem. Sci. 17:470–473.
Thomas, J., Webb, W., Davitz, M. A., and Nussenzweig, V., 1987, Decay-accelerating factor diffuses rapidly on Hela (AE) cell surfaces, Biophys. J. 51(issue 2, part 2):522a.
Tse, A.G.D., Barclay, A. N., Watts, A., and Williams, A. F., 1985, A glycophospholipid tail at the carboxyl terminus of the Thy-1 glycoprotein of neurons and thymocytes, Science 230:1003–1008.
Urakaze, M., Kamitoni, T., DeGasperi, R., Sugiyama, E., Chang, H., and Yeh, E.T.H., 1992, Identification of a missing link in GPI anchor biosynthesis in mammalian cells, J. Biol. Chem. 267:6459–6462.
Vidugiriene, J., and Menon, A. K., 1994, The GPI anchor of cell-surface proteins is synthesized on the cytoplasmic face of the endoplasmic reticulum, J. Cell Biol. 127:333–341.
Waneck, G. L., Stein, M. E., and Flavell, R. A., 1988, Conversion of a PI-anchored protein to an integral membrane protein by a single amino acid mutation, Science 241:697–699.
Witters, L. A., and Watts, T. D., 1988, An autocrine factor from Reuber hepatoma cells that stimulates DNA synthesis and acetyl-CoA carboxylase: Characterization of biologic activity and evidence for a glycan structure, J. Biol. Chem. 263:8027–8036.
Witters, L. A., Watts, T. D., Gould, G. W., Lienhard, G. E., and Gibbs, E. M., 1987, Regulation of protein phosphorylation by insulin and an insulin-mimetic oligosaccharide in 3T3-L1 adipocytes and FaO hepatoma cells, Biochem. Biophys. Res. Commun. 153:992–998.
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© 1996 Plenum Press, New York
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Saltiel, A.R. (1996). Structural and Functional Roles of Glycosylphosphoinositides. In: Biswas, B.B., Biswas, S. (eds) myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction. Subcellular Biochemistry, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0343-5_6
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