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Control of the Ca2+ Release Induced by myo-Inositol Trisphosphate and the Implication in Signal Transduction

  • Ludwig Missiaen
  • Jan B. Parys
  • Humbert De Smedt
  • Ilse Sienaert
  • Martin D. Bootman
  • Rik Casteels
Part of the Subcellular Biochemistry book series (SCBI, volume 26)

Abstract

Inositol-1,4,5-trisphosphate (InsP3) is a diffusible messenger formed within the cell in response to external stimuli. It mobilizes Ca2+ from those nonmitochondrial Ca2+ pools that express the InsP3 receptor (InsP3R), a specific Ca2+-release channel (Berridge and Irvine, 1989; Berridge, 1993). The nonmitochondrial pools were originally classified as InsP3-sensitive and InsP3insensitive. Recent evidence suggests that the InsP3-sensitive Ca2+ pool is much larger than hitherto expected (Bird et al., 1992) and that InsP3-insensitive Ca2+ pools can artifactually be formed during the permeabilization procedure (Hajnóczky et al., 1994). Under conditions of very mild permeabilization, 95% of the nonmitochondrial Ca2+ pools can be InsP3-sensitive, e.g., in A7r5 smooth muscle cells (Missiaen et al., 1992b).

Keywords

Calcium Release Ryanodine Receptor Inositol Phosphate Pancreatic Acinar Cell Inositol Trisphosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this Chapter

InsP3

inositol-1,4,5-trisphosphate

InsP3R

InsP3 receptor

PK A

cyclic- AMP-dependent protein kinase

PKG

cyclic-GMP-dependent protein kinase

[Ca2+]

Ca2+ concentration

[Ca2+]i

cytosolic Ca2+ concentration

PCR

polymerase chain reaction

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Ludwig Missiaen
    • 1
  • Jan B. Parys
    • 1
  • Humbert De Smedt
    • 1
  • Ilse Sienaert
    • 1
  • Martin D. Bootman
    • 2
  • Rik Casteels
    • 1
  1. 1.Laboratory for PhysiologyCatholic University of LeuvenLeuvenBelgium
  2. 2.The Babraham Institute Laboratory of Molecular Signaling, Department of ZoologyCambridge UniversityCambridgeUK

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