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Phosphoinositides and Synaptic Transmission

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myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction

Part of the book series: Subcellular Biochemistry ((SCBI,volume 26))

Abstract

The isolation of a “diphosphoinositide” fraction from ox brain by Folch (1949) and the observation by Dawson (1954) that radioactive phosphate was rapidly incorporated into its lipids laid the foundations of our present knowledge of the brain phosphoinositides. The structures of the major phosphoinositides, phosphatidylinositol (I), phosphatidylinositol-4 phosphate (II) and phosphatidylinositol-4,5-biphosphate (III) are given in Figure 1. The generally accepted abbreviations used in this chapter are Ptdlns (I), PtdIns 4-P (II), and PtdIns 4,5-P2 (III).

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  1. John N. Hawthorne

    Present address: International Medical College, 46050, Petaling Jaya, Selangor D.H., Malaysia

Authors and Affiliations

  1. Department of Biochemistry, Medical School, Queen’s Medical Centre, Nottingham, NG7 2UH, UK

    John N. Hawthorne

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  1. John N. Hawthorne
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Editors and Affiliations

  1. University of Calcutta, Calcutta, India

    B. B. Biswas

  2. Bose Institute, Calcutta, India

    Susweta Biswas

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© 1996 Plenum Press, New York

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Hawthorne, J.N. (1996). Phosphoinositides and Synaptic Transmission. In: Biswas, B.B., Biswas, S. (eds) myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction. Subcellular Biochemistry, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0343-5_2

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  • DOI: https://doi.org/10.1007/978-1-4613-0343-5_2

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