Abstract
Elucidation of the cellular origin of the Hodgkin and Reed-Sternberg cells (H-RS) cells, the tumour cells of Hodgkin’s disease (HD), is made difficult by the fact that these cells represent only a small minority of the cellular infiltrate in tissues affected by HD. Neither the study of cell lines nor the study of DNA or RNA extracted from HD-lymph nodes has been able to conclusively solve some of the most interesting questions, e.g., the questions of origin and clonality of the H-RS cells, the role of viruses in the pathogenesis of HD and the role of soluble and cell-bound signals in the maintenance of the malignant phenotype.
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© 1995 Plenum Press, New York
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Trümper, L., Daus, H., Roth, J., Loftin, U., Gause, A., Pfreundschuh, M. (1995). Single Cell PCR at the DNA and RNA Level: A Novel Approach to the Study of Hodgkin’s Disease. In: Jarrett, R.F. (eds) Etiology of Hodgkin’s Disease. NATO ASI Series, vol 280. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0339-8_12
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DOI: https://doi.org/10.1007/978-1-4613-0339-8_12
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