CD30 Ligand: Cloning, Characterisation and Biological Activities
Hodgkin’s disease (HD) is characterised by the presence of a small number (< 1% of total tumour mass) of the typical, presumed malignant Hodgkin and Reed-Sternberg (H-RS) cells in a hyperplastic background of normal, reactive lymphocytes, plasma cells, histiocytes, neutrophils, eosinophils, and stromal cells. The histopathological presentation and characteristic clinical features of HD correlate with an unbalanced production of multiple cytokines. H-RS cells produce various growth factors, cytokine receptors and activation antigens, implying a role for growth factors in the pathophysiology of HD. HD may therefore be characterised as a tumour of cytokine producing cells. The CD30 antigen has been described as a marker for cultured and primary H-RS cells, and found to be overexpressed in HD and some large cell anaplastic non-Hodgkin’s lymphoma cases. The molecular cloning of the CD30 antigen revealed that CD30 is a member of the tumour necrosis factor/nerve growth factor receptor superfamily. The cloning of the cognate for CD30, currently termed CD30 ligand, confirmed that the CD30 antigen functions as a cytokine receptor. Recombinant CD30 ligand is a type-II membrane-associated protein with pleiotropic biological activities for different CD30+ lymphoma types, but also normal immune system cells, predominantly T-cells. CD30L belongs to the emerging tumour necrosis factor ligand superfamily by virtue of homology to CD27L, CD40L, TNF and other members. These findings suggest that CD30-CD30L interactions could have a pathophysiological role in HD and large cell anaplastic lymphomas, and could also be involved in the activation and function of the immune system, particularly T-cell responses.
KeywordsLymphoma Codon Leukemia Recombination Titration
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