Supporting Tissue Oxygenation During Acute Surgical Bleeding Using A Perfluorochemical-Based Oxygen Carrier

  • Peter E. Keipert
  • N. Simon Faithfull
  • Duane J. Roth
  • JoAnn D. Bradley
  • Sanjay Batra
  • Philip Jochelson
  • Kathryn E. Flaim
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)


Attempts to develop so-called “blood substitutes” have historically focused on three approaches: 1) acellular hemoglobin (Hb) solutions, 2) encapsulation of Hb, and 3) perfluorochemical emulsions. Work on Hb solutions first began over 100 years ago,1 by lysing red blood cells to extract the oxygen-carrying Hb molecules. For the past 60 years, efforts have concentrated on purifying the Hb from the contaminating stromal lipid,2 and on developing ways to crosslink or polymerize the Hb molecules3 to prevent them from splitting into dimers (i.e., half-molecules) which are rapidly filtered by the kidney. Based on the fact that free Hb has a very short intravascular persistence and is potentially toxic to the kidney,4 some investigators have used microencapsulation as a means to package the Hb inside sub-micron lipid-coated vesicles.5,6


Oxygen Carrier Allogeneic Blood Surgical Bleeding Total Oxygen Consumption Acute Normovolemic Hemodilution 
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Copyright information

© Plenum Press,New York 1996

Authors and Affiliations

  • Peter E. Keipert
    • 1
  • N. Simon Faithfull
    • 1
  • Duane J. Roth
    • 1
  • JoAnn D. Bradley
    • 1
  • Sanjay Batra
    • 1
  • Philip Jochelson
    • 1
  • Kathryn E. Flaim
    • 1
  1. 1.Alliance Pharmaceutical CorporationSan DiegoUSA

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