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Oxygen Tension in Isotransplanted Mammary Carcinomas and Osteosarcomas Before and After Irradiation

  • Chapter
Oxygen Transport to Tissue XVII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 388))

Abstract

The studies of Chapman (1), Thomlinson and Gray (27,28) infered the presence and significance of hypoxic cells in malignant tumors. Numerous publications indicate, that tumor cells with low oxygen tensions are relatively resistant towards irradiation and some chemotherapy regimes (3,9,10,13,14,24). However, the prognostic significance of hypoxia and reoxygenation remain uncertain (2,3,6,9,10,11,12,19). With the Eppendorf pO2-histographR a novel technique for oxygen measurement became practicable (5,17,21,22,32,33). We started to use this device under experimental conditions. The objective of this study was to investigate pO2-distributions in isotransplanted mammary carcinomas and osteosarcomas of various sizes before and after irradiation with different single doses.

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Author information

Authors and Affiliations

  1. Clinic and Policlinic for Radiotherapy and Radiological Oncology, Germany

    L. Weissfloch, T. Auberger, H. J. Feldmann & M. Molls

  2. Clinic and Policlinic for Nuclearmedicine, TU München, Ismaninger Str. 22, D-81675, München, Germany

    R. Senekowitsch

  3. Institute for Pharmacology, Toxicology und Pharmacy, Veterinary Faculty, LMU Munich, Königinstr. 16/11, D-80539, München, Germany

    K. Tempel

Authors
  1. L. Weissfloch
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  2. T. Auberger
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  4. R. Senekowitsch
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  5. K. Tempel
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  6. M. Molls
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Editors and Affiliations

  1. Academic Medical Center, Amsterdam, The Netherlands

    C. Ince  & J. Kesecioglu  & 

  2. University of Istanbul, Istanbul, Turkey

    L. Telci  & K. Akpir  & 

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© 1996 Plenum Press New York

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Weissfloch, L., Auberger, T., Feldmann, H.J., Senekowitsch, R., Tempel, K., Molls, M. (1996). Oxygen Tension in Isotransplanted Mammary Carcinomas and Osteosarcomas Before and After Irradiation. In: Ince, C., Kesecioglu, J., Telci, L., Akpir, K. (eds) Oxygen Transport to Tissue XVII. Advances in Experimental Medicine and Biology, vol 388. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0333-6_63

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  • DOI: https://doi.org/10.1007/978-1-4613-0333-6_63

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8002-3

  • Online ISBN: 978-1-4613-0333-6

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