Tissue becomes ischemic when the blood supply does not match its needs resulting in an inadequate oxygen delivery, i.e., hypoxia. In contrast to other forms of hypoxia, the washout of metabolites and heat are also impeded. Myocardial ischemia is by far the most common cause of cardiac hypoxia. In clinical terms, it may be defined as dysfunction of cardiac myocytes resulting from hypoxia due to limited coronary blood flow. It is usually detected by a shift of an ST-segment on the ECG. Most experimental and virtually all clinical studies of myocardial ischemia concentrate on the pathology of coronary arteries. The coronary microcirculation, however, may play an important role in cardiac ischemia both as its possible cause as well as in the tissue response to this insult.
KeywordsObesity Depression Ischemia NADH Cardiol
Unable to display preview. Download preview PDF.
- Cicutti, N., Rakusan, K. and Downey, H.F., in press, Coronary artery occlusion extends perfusion territory boundaries through microvascular collaterals, Bas. Res. Cardiol, in press.Google Scholar
- Kaski, J.C., 1993, Myocardial ischaemia in the hypertensive patient - the role of coronary microcirculation abnormalities, Europ. Heart J. 14(Suppl. J):32–37.Google Scholar
- Likoff, W., Segal, B.L. and Kasparian, H, Parades of normal selective coronary arteriograms in patients considered to have unmistakable coronary heart disease, N. Engl. J. Med. 276:1063–1066.Google Scholar