Ischemic Heart

Microcirculatory Aspects
  • Karel Rakusan
  • Nicholas Cicutti
  • Tomas Sladek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)


Tissue becomes ischemic when the blood supply does not match its needs resulting in an inadequate oxygen delivery, i.e., hypoxia. In contrast to other forms of hypoxia, the washout of metabolites and heat are also impeded. Myocardial ischemia is by far the most common cause of cardiac hypoxia. In clinical terms, it may be defined as dysfunction of cardiac myocytes resulting from hypoxia due to limited coronary blood flow. It is usually detected by a shift of an ST-segment on the ECG. Most experimental and virtually all clinical studies of myocardial ischemia concentrate on the pathology of coronary arteries. The coronary microcirculation, however, may play an important role in cardiac ischemia both as its possible cause as well as in the tissue response to this insult.


Infarcted Heart Infarcted Region Coronary Artery Ligation Coronary Microcirculation Microvascular Anastomosis 
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Copyright information

© Plenum Press New York 1996

Authors and Affiliations

  • Karel Rakusan
    • 1
  • Nicholas Cicutti
    • 1
  • Tomas Sladek
    • 1
  1. 1.Department of Physiology Faculty of MedicineUniversity of OttawaOttawaCanada

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