Abstract
The presence of hypoxic fractions has been shown in experimental tumour models3, 12, 13, 16,19 as well as in human tumours6, 19, related to the tumour size and tumour growth rate. In clinical oncology several treatment modalities have been applied to overcome tumour hypoxia e.g., hyperthermia, chemical modifiers of tumour blood flow, hypervolemic blood transfusion, hypoxic cell sensitizers (e.g. misonidasole), hyperbaric oxygen (HBO)7. Of all the different radiation enhancement factors, oxygen possesses the highest enhancement ratio, 2.7 to 3.0, provided that molecular oxygen is present during irradiation to act as such20. The efficacy of HBO in decreasing radioresistance in tumours has been shown in experimental studies5, 11, as well as in clinical trials.9 Furthermore, it has been shown that oxygen tension distributions in human breast tumours19 and cervix carcinoma2, 8 are sufficient to estimate the radiation response. Controlled trials with HBO have shown a 60% benefit, whereas in trials with misonidasole only a 21% benefit has been established14. A recent phase 2 study in our institution21 showed an increase of the twenty-eight months cumulative survival rate from 12% to 28% in patients treated with radioactive Methyl-131 Iodine Benzyl Guadinine (M-131IBG) combined with HBO, compared with a similar group of patients in a preceded period treated previously with M-131IBG without HBO. Two factors can be identified which could have contributed to these results. First, an unsealed source radiation brachytherapy was used during the HBO therapy. Secondly, a neuroblastoma cell is biochemically characterized by reduced endogenous defence mechanisms to oxygen derived free radicals9,17. These encouraging results prompted us to investigate the feasibility of sealed source brachytherapy combined with HBO therapy for solid tumours. Therefore we were interested in the time resolution of the oxygen tension distribution in an experimental tumour model with a Polarographie needle electrode during normobaric (FiO2: 21%) and hyperbaric (FiO2: 21% and FiO2: 100%) conditions without irradiation.
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van der Kleij, A.J., Kooijman, R., Kipp, J.B.A., Obertop, H. (1996). Tumour Oxygenation. In: Ince, C., Kesecioglu, J., Telci, L., Akpir, K. (eds) Oxygen Transport to Tissue XVII. Advances in Experimental Medicine and Biology, vol 388. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0333-6_51
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DOI: https://doi.org/10.1007/978-1-4613-0333-6_51
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