Lightguide Spectrophotometry for the Assessment of Skin Healing Viability in Critical Limb Ischaemia

  • D. K. Harrison
  • D. J. Newton
  • P. T. McCollum
  • A. S. Jain
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)


Techniques in vascular surgery and medicine have advanced considerably over the last decade. Whereas, in the past, critical ischaemia of the lower limb frequently resulted in amputation, nowadays, even lower limbs subject to occlusion of distal arteries can frequently be salvaged (Shah et al, 1992). Nonetheless, currently, of about 5000 patient visits per year to our Vascular Laboratory, some 100 of those patients with critical limb ischaemia (CLI) ultimately still need to undergo an amputation. Whether a below knee amputation is viable or not is currently predicted in our laboratory by means of skin blood flow measurements made at the site of the proposed skin flap (McCollum et al, 1985).


Skin Flap Critical Limb Ischaemia Skin Blood Flow Capillary Blood Flow Critical Ischaemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Egglishaw, C, 1994 Quantification of catchment volumes of MCPD and EMPHO spectrophotometers, for visible wavelengths, using an in vivo model of the skin, Hons. Disstn., Dept. App. Phys. Elect, and Manuf. Eng., Univ. Dundee.Google Scholar
  2. Harrison, D. K., and Walker, W. F., 1979, Microelectrode measurement of skin pH in humans during ischaemia, hypoxia and local hypothermia, J. Physiol. (Lond.) 291:339–350.Google Scholar
  3. Harrison, D. K., Birkenhake, S., Hagen, N., and Kessler, M., 1989, Capillary blood flow and local oxygen supply in skeletal muscle during acute haemodilution with hydroxyethyl starch, Adv. Exp. Med. Biol. 248:693–698.PubMedGoogle Scholar
  4. Harrison, D. K., Kessler, M., and Knauf, S. K., 1990, Regulation of capillary blood flow and oxygen supply in skeletal muscle in dogs during hypoxaemia, J. Physiol. (Lond.) 420:431–446.Google Scholar
  5. Harrison, D. K., Evans, S. D., Abbot, N. C., Swanson Beck, J., and McCollum, P. T., 1992, Spectrophotometric measurements of haemoglobin saturation and concentration in skin during the tuberculin reaction in normal human subjects, Clin. Phys. & Physiol. Meas. 13:349–363.CrossRefGoogle Scholar
  6. Harrison, D. K., Abbot, N. C., Swanson Beck J., and McCollum, P. T., 1993, Preliminary assessment of laser Doppler imaging for measurement of skin perfusion using the tuberculin reaction in human skin as a model, Phys. Meas. 14:241–252.CrossRefGoogle Scholar
  7. Hickman, P., Walker, M.A., Harrison, D., Belch, J., and McCollum P.T,, 1992, Use of lightguide reflectance spectrophotometry in the assessment of peripheral arterial disease, Br. J. Surg. 79:361.Google Scholar
  8. Kessler, M., Höper, J., Harrison, D. K., Skolasinska, K., Klövekorn, W. P., Sebening, F., Volkholz, H. J., Beier, I., Kernbach, C, Rettig, V., and Richter, H., 1984, Tissue 02 supply under normal and pathological conditions, Adv. Exp. Med. Biol. 169:69–80.PubMedGoogle Scholar
  9. McCollum, P.T., Spence, V. A., and Walker, W. F., 1985, Circumferential skin blood flow measurements in the ischaemic limb, Br. J. Surg. 72:310–312.PubMedCrossRefGoogle Scholar
  10. McCollum, P. T., Spence, V. A., and Walker, W. F., 1988, Amputation for peripheral vascular disease: the case for level selection, Br. J. Surg. 75:1193–1195.PubMedCrossRefGoogle Scholar
  11. Shah, D. M., Darling, R. C. III., Chang, B. B., Kaufman, J. L., Fitzgerald, K. M., and Leather, R. P., 1992, Is long vein bypass from groin to ankle a durable procedure? An analysis of a ten-year experience, J. Vasc. Surg. 15:402–407.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • D. K. Harrison
    • 1
  • D. J. Newton
    • 1
  • P. T. McCollum
    • 2
  • A. S. Jain
    • 3
  1. 1.Department of Medical PhysicsDundeeScotland, UK
  2. 2.Department of Surgery Vascular LaboratoryNinewells Hospital and Medical SchoolDundeeScotland, UK
  3. 3.Department of Orthopaedic SurgeryDundee Royal InfirmaryDundeeScotland, UK

Personalised recommendations