Fractionation Effects of Oxygen Isotopes Within Interstitial Lung Disease

  • H. Heller
  • M. Könen
  • A. Overlack
  • K. -D. Schuster
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)


Up to now diffusion limitation versus ventilation-perfusion inhomogeneities are in dispute as the main reason for impairing pulmonary gas exchange within interstitial lung diseases (Finley et al., 1962, Wagner et al., 1976, Jernudd-Wilhelmsson et al., 1986, Agusti et al., 1987, Hempleman and Hughes, 1991, Hughes et al., 1991, Yamaguchi et al., 1991). In order to assess pulmonary gas transport, such methods as the estimation of the arterial partial pressure of oxygen during nitrogen washout (Finley et al., 1962), the multiple inert gas elimination technique (Wagner et al., 1976, Jernudd-Wilhelmsson et al., 1986, Agusti et al., 1987, Hughes et al., 1991, Yamaguchi et al., 1991) and the determination of the single breath diffusing capacity for carbon monoxide (Finley et al., 1962, Wagner et al., 1976, Hughes et al., 1991) have been applied.


Oxygen Isotope Idiopathic Pulmonary Fibrosis Pulmonary Fibrosis Interstitial Lung Disease Fractionation Effect 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • H. Heller
    • 1
  • M. Könen
    • 1
  • A. Overlack
    • 2
  • K. -D. Schuster
    • 1
  1. 1.Physiologisches Institut IUniversität BonnBonnGermany
  2. 2.Medizinische Universitäts-Poliklinik BonnBonnGermany

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