The Changes of Skin and Mesenteric Mirovascular Permeability in Adaptation to Hypoxia in Rats

  • M. V. Dubina
  • N. A. Gavrisheva
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)


Character of changes in permeability of vessels in hypoxia depends on degree of tension of process supplying the lack of oxygen in tissues. The changes of microcirculation in hypoxia depend on many factors, in particular - level and duration of activity, compensate possibilities of organism, endothelial sensitivity to vasoactive substances etc. One of the effective methods to raise the resistance of an organism to oxygen lack is intermittent hypoxia (Vorontsov & Rusanova, 1987). It is known that the endothelium has a barrier function, with vessel permeability as one of its indices (Ogawa, et al., 1990). Barrier characteristics of the endothelium of microvessels are defined in many respects by structure-functional peculiarities of organs. Hence, in our experiments we examined the permeability of microvessels of rat skin and mesentery on different stages of adaptation to intermittent hypobaric hypoxia.


Intermittent Hypoxia Hypobaric Hypoxia Vasoactive Substance Microvascular Permeability Barrier Characteristic 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • M. V. Dubina
    • 1
  • N. A. Gavrisheva
    • 1
  1. 1.Department of PathophysiologySt. Petersburg Pavlov Medical UniversitySt. PetersburgRussia

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