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Fluctuations in the Oxygenation of Experimental Tumours

  • Andrew I. Minchinton
  • Karen H. Fryer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)

Abstract

The outcome of therapy for solid tumours is modulated by many factors (Hall, 1978). The most important modulator of response to radiation therapy is the presence of oxygen. Cells that are severely hypoxic are approximately 3 times more resistant to low LET radiation (used in radiotherapy) than well oxygenated cells. Chemotherapeutic efficacy may also be adversely affected by oxygen deprivation (Tannock & Guttman, 1981).

Keywords

Oxygen Tension Experimental Tumour Histological Structure Oxygen Deprivation Chemotherapeutic Efficacy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Brown, J. M. (1979). Evidence for acutely hypoxic cells in mouse tumours and a possible mechanism of reoxygenation. Br. J. Radiol., 52, 650–656.PubMedCrossRefGoogle Scholar
  2. Hall, E. J. (1978). Radiobiology for radiologists (2nd ed.). Philadelphia: Harper & Row.Google Scholar
  3. Minchinton, A. I. (In press). Differences in the tumour oxygen tension in mice and man. Acta Oncologica, Tannock, I., & Guttman, P. (1981). Response of Chinese hamster ovary cells to anti-cancer drugs under aerobic and hypoxic conditions. Br. J. Cancer, 43, 245–248.Google Scholar
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Andrew I. Minchinton
    • 1
  • Karen H. Fryer
    • 1
  1. 1.B.C. Cancer Research CentreVancouverCanada

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