Fluctuations in the Oxygenation of Experimental Tumours
The outcome of therapy for solid tumours is modulated by many factors (Hall, 1978). The most important modulator of response to radiation therapy is the presence of oxygen. Cells that are severely hypoxic are approximately 3 times more resistant to low LET radiation (used in radiotherapy) than well oxygenated cells. Chemotherapeutic efficacy may also be adversely affected by oxygen deprivation (Tannock & Guttman, 1981).
KeywordsOxygen Tension Experimental Tumour Histological Structure Oxygen Deprivation Chemotherapeutic Efficacy
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