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Extra- and Intracellular Oxygen Supply During Cortical Spreading Depression in the Rat

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Oxygen Transport to Tissue XVII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 388))

Abstract

Cortical Spreading Depression was discovered fifty years ago 15, but the complexity of its mechanisms is still far from being understood. It was then the high time of Wolff’s vascular theory of migraine 25 when Lashley first calculated the velocity of a supposed electrophysiological phenomenon in the primary visual cortex that could cause the optical hallucinations of the migraine aura as the same velocity that characterizes CSD 12. Aróle for CSD in the pathophysiological scenario of migraine has become more and more attractive ever since, mainly by virtue of accumulating evidence for neuronal mechanisms as found in the pursuit of Moskowitz’ theory of neurogenic inflammation in migraine 14,l7.

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Author information

Authors and Affiliations

  1. Department of Neurology, Humboldt University, Berlin, Germany

    T. Wolf, U. Lindauer, H. Obrig, A. Villringer & U. Dirnagl

Authors
  1. T. Wolf
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  2. U. Lindauer
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  3. H. Obrig
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  4. A. Villringer
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  5. U. Dirnagl
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Editor information

Editors and Affiliations

  1. Academic Medical Center, Amsterdam, The Netherlands

    C. Ince  & J. Kesecioglu  & 

  2. University of Istanbul, Istanbul, Turkey

    L. Telci  & K. Akpir  & 

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© 1996 Plenum Press, New York

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Wolf, T., Lindauer, U., Obrig, H., Villringer, A., Dirnagl, U. (1996). Extra- and Intracellular Oxygen Supply During Cortical Spreading Depression in the Rat. In: Ince, C., Kesecioglu, J., Telci, L., Akpir, K. (eds) Oxygen Transport to Tissue XVII. Advances in Experimental Medicine and Biology, vol 388. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0333-6_38

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  • DOI: https://doi.org/10.1007/978-1-4613-0333-6_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8002-3

  • Online ISBN: 978-1-4613-0333-6

  • eBook Packages: Springer Book Archive

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