Extra- and Intracellular Oxygen Supply During Cortical Spreading Depression in the Rat

  • T. Wolf
  • U. Lindauer
  • H. Obrig
  • A. Villringer
  • U. Dirnagl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)


Cortical Spreading Depression was discovered fifty years ago 15, but the complexity of its mechanisms is still far from being understood. It was then the high time of Wolff’s vascular theory of migraine 25 when Lashley first calculated the velocity of a supposed electrophysiological phenomenon in the primary visual cortex that could cause the optical hallucinations of the migraine aura as the same velocity that characterizes CSD 12. Aróle for CSD in the pathophysiological scenario of migraine has become more and more attractive ever since, mainly by virtue of accumulating evidence for neuronal mechanisms as found in the pursuit of Moskowitz’ theory of neurogenic inflammation in migraine 14,l7.


Cortical Spreading Depression Near Infrared Spectroscopy Spreading Depression Migraine Aura Potassium Chloride Solution 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • T. Wolf
    • 1
  • U. Lindauer
    • 1
  • H. Obrig
    • 1
  • A. Villringer
    • 1
  • U. Dirnagl
    • 1
  1. 1.Department of NeurologyHumboldt UniversityBerlinGermany

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